Academic Journal
Identifying interindividual variability of social perception and associated brain anatomical correlations in children with autism spectrum disorder using eye-tracking and diffusion tensor imaging MRI (DTI-MRI)
| العنوان: | Identifying interindividual variability of social perception and associated brain anatomical correlations in children with autism spectrum disorder using eye-tracking and diffusion tensor imaging MRI (DTI-MRI) |
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| المؤلفون: | Vinçon-Leite, Alice, Saitovitch, Ana, Lemaître, Herve, Rechtman, Elza, Boisgontier, Jennifer, Fillon, Ludovic, Philippe, Anne, Rio, Marlène, Desguerre, Isabelle, Fabre, Aurélie, Aljabali, Khawla, Boddaert, Nathalie, Zilbovicius, Monica |
| المساهمون: | Trajectoires développementales en psychiatrie : mesures et modélisations (ERL Inserm U1299), CB - Centre Borelli - UMR 9010 (CB), Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité)-Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut des Maladies Neurodégénératives Bordeaux (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité), Université Paris Cité (UPCité), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), This work was supported by Fondation Orange and Fondation de France. |
| المصدر: | ISSN: 1047-3211. |
| بيانات النشر: | HAL CCSD Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | DTI-MRI, autism spectrum disorder, eye-tracking, fractional anisotropy, social perception, MESH: Child, MESH: Humans, MESH: Diffusion Tensor Imaging, MESH: Autism Spectrum Disorder, MESH: Eye-Tracking Technology, MESH: Brain, MESH: Magnetic Resonance Imaging, MESH: White Matter, MESH: Social Perception, MESH: Anisotropy, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Abstract Even though deficits in social cognition constitute a core characteristic of autism spectrum disorders, a large heterogeneity exists regarding individual social performances and its neural basis remains poorly investigated. Here, we used eye-tracking to objectively measure interindividual variability in social perception and its correlation with white matter microstructure, measured with diffusion tensor imaging MRI, in 25 children with autism spectrum disorder (8.5 ± 3.8 years). Beyond confirming deficits in social perception in participants with autism spectrum disorder compared 24 typically developing controls (10.5 ± 2.9 years), results revealed a large interindividual variability of such behavior among individuals with autism spectrum disorder. Whole-brain analysis showed in both autism spectrum disorder and typically developing groups a positive correlation between number of fixations to the eyes and fractional anisotropy values mainly in right and left superior longitudinal tracts. In children with autism spectrum disorder a correlation was also observed in right and left inferior longitudinal tracts. Importantly, a significant interaction between group and number of fixations to the eyes was observed within the anterior portion of the right inferior longitudinal fasciculus, mainly in the right anterior temporal region. This additional correlation in a supplementary region suggests the existence of a compensatory brain mechanism, which may support enhanced performance in social perception among children with autism spectrum disorder. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38037470; hal-04484655; https://hal.science/hal-04484655; https://hal.science/hal-04484655v1/document; https://hal.science/hal-04484655v1/file/bhad434.pdf; PUBMED: 38037470; PUBMEDCENTRAL: PMC10793563 |
| DOI: | 10.1093/cercor/bhad434 |
| الاتاحة: | https://hal.science/hal-04484655 https://hal.science/hal-04484655v1/document https://hal.science/hal-04484655v1/file/bhad434.pdf https://doi.org/10.1093/cercor/bhad434 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.4A788EB1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cercor/bhad434 |
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