Academic Journal
The contribution of infection and the respiratory microbiome in acute exacerbations of idiopathic pulmonary fibrosis
| العنوان: | The contribution of infection and the respiratory microbiome in acute exacerbations of idiopathic pulmonary fibrosis |
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| المؤلفون: | Invernizzi, R, Molyneaux, PL |
| بيانات النشر: | European Respiratory Society |
| سنة النشر: | 2019 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Respiratory System |
| جغرافية الموضوع: | England |
| الوصف: | Idiopathic pulmonary fibrosis (IPF) arises in genetically susceptible individuals as a result of an aberrant wound-healing response following repetitive alveolar injury. The clinical course of the disease remains both variable and unpredictable with periods of more rapid decline, termed acute exacerbation of IPF (AE-IPF), often punctuating the disease trajectory. Exacerbations carry a significant morbidity and mortality, and their exact pathogenesis remains unclear. Given the emerging evidence that disruption and alteration in the lung microbiome plays a role in the pathogenesis and progression of IPF, this review discusses the current knowledge of the contribution of infection and the respiratory microbiome to AE-IPF. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0905-9180 |
| Relation: | European Respiratory Review; http://hdl.handle.net/10044/1/72274; https://dx.doi.org/10.1183/16000617.0045-2019 |
| DOI: | 10.1183/16000617.0045-2019 |
| الاتاحة: | http://hdl.handle.net/10044/1/72274 https://doi.org/10.1183/16000617.0045-2019 |
| Rights: | ©ERS 2019. http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0 (https://creativecommons.org/licenses/by/4.0/) |
| رقم الانضمام: | edsbas.4A11D45D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09059180 |
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| DOI: | 10.1183/16000617.0045-2019 |