التفاصيل البيبلوغرافية
| العنوان: |
Bacterial Colonization of the Lower Airways in Children With Esophageal Atresia |
| المؤلفون: |
van Tuyll van Serooskerken, Eleonora Sofie, Duhoky, Rauand, Verweij, Johannes W, Bont, Louis, Arets, Hubertus G M, Bittermann, Arnold J N, van der Zee, David C, Tytgat, Stefaan H A J, Lindeboom, Maud Y A |
| المساهمون: |
Zorgeenheid Kinderchirurgie Medisch, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Longziekten patientenzorg, MS KNO, Brain |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
bronchoalveolar lavage, esophageal atresia, lower airway bacterial colonization, respiratory tract infections, Microbiology (medical), Infectious Diseases, Pediatrics, Perinatology, and Child Health, Journal Article |
| الوصف: |
BACKGROUND: Esophageal atresia (EA) is most often accompanied by some degree of tracheomalacia (TM), which negatively influences the airway by ineffective clearance of secretions. This can lead to lower airway bacterial colonization (LABC), which may cause recurrent respiratory tract infections (RTIs). This study aims to evaluate the prevalence and specific pathogens of LABC in EA patients. METHODS: A 5-year retrospective single-site cohort study was conducted including all EA patients that had undergone an intraoperative bronchoalveolar lavage (BAL) during various routine surgical interventions. Concentrations of greater than 10 cfu were considered evidence of LABC. RESULTS: We recruited 68 EA patients, of which 12 were excluded based on the exclusion criteria. In the remaining 56 patients, a total of 90 BAL samples were obtained. In 57% of the patients, at least 1 BAL sample was positive for LABC. Respiratory symptoms were reported in 21 patients at the time of the BAL, of which 10 (48%) had LABC. Haemophilus influenzae (14%) and Staphylococcus aureus (16%) were most frequently found in the BAL samples. The number of respiratory tract infections and the existence of a recurrent fistula were significantly associated with LABC (P = 0.008 and P = 0.04, respectively). CONCLUSIONS: This is the first study showing that patients with EA have a high prevalence of bacterial colonization of the lower airways which may be a leading mechanism of severe and recurrent respiratory complications. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0891-3668 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/449147 |
| الاتاحة: |
https://dspace.library.uu.nl/handle/1874/449147 |
| Rights: |
info:eu-repo/semantics/ClosedAccess |
| رقم الانضمام: |
edsbas.4A0BBFB8 |
| قاعدة البيانات: |
BASE |