Academic Journal
Human Papillomavirus Coinfection in the Cervical Intraepithelial Lesions and Cancer of Mexican Patients
| العنوان: | Human Papillomavirus Coinfection in the Cervical Intraepithelial Lesions and Cancer of Mexican Patients |
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| المؤلفون: | Padilla-Mendoza, Juan Ramón, Gómez-López, Lucía Angélica, López-Casamichana, Mavil, Azuara-Liceaga, Elisa Irene, Cortés-Malagón, Enoc Mariano, López-Cánovas, Lilia, Reyes-Hernández, Octavio Daniel, Rodríguez, Mario Alberto, Bonilla-Delgado, José, López-Reyes, Israel |
| المساهمون: | Banche, Giuliana, Consejo Nacional de Ciencia y Tecnología |
| المصدر: | BioMed Research International ; volume 2020, issue 1 ; ISSN 2314-6133 2314-6141 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | According to their oncogenic properties, Human Papillomaviruses (HPVs) are classified into two types: Low‐Risk (LR‐HPVs) and High‐Risk Human Papillomaviruses (HR‐HPVs). The immune system naturally controls the majority of HPV infections; however, when the HR‐HPV infection is persistent, the risk of developing cervical cancer increases. Previous studies indicate that multiple‐infection or coinfection with HR‐HPV occurs frequently and can potentiate the development of cervical lesions. This study aimed to establish the HPV coinfection rate in squamous intraepithelial lesions from Mexican patients. For HPV detection, we performed PCR on 55 cervical lesions diagnosed by colposcopy. We detected the presence of HPV infection in 87.27% (48/55) of the lesions; interestingly, HPV coinfection was observed in 70.83% (34/48) of these samples. We also evaluated HPV infection in adjacent areas without morphological changes from 25 samples. The results showed that 80% (20/25) of these were HPV‐positive and, curiously, all presented HPV‐16 infection. In conclusion, our results revealed a high prevalence of HPV coinfection in cervical lesions in Mexican patients, and these results contribute to future research focused on the role that HPV coinfection plays in the development of cervical cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1155/2020/4542320 |
| الاتاحة: | https://doi.org/10.1155/2020/4542320 http://downloads.hindawi.com/journals/bmri/2020/4542320.pdf http://downloads.hindawi.com/journals/bmri/2020/4542320.xml https://onlinelibrary.wiley.com/doi/pdf/10.1155/2020/4542320 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.4A0994DA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2020/4542320 |
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