Academic Journal
Ceramic‐hydrogel composite as carrier for cold‐plasma reactive‐species: Safety and osteogenic capacity in vivo
| العنوان: | Ceramic‐hydrogel composite as carrier for cold‐plasma reactive‐species: Safety and osteogenic capacity in vivo |
|---|---|
| المؤلفون: | Solé‐Martí, Xavi, Labay, Cédric, Raymond, Yago, Franch, Jordi, Benitez, Raul, Ginebra, Maria‐Pau, Canal, Cristina |
| المساهمون: | H2020 European Research Council |
| المصدر: | Plasma Processes and Polymers ; volume 20, issue 1 ; ISSN 1612-8850 1612-8869 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Plasma‐treated hydrogels have been put forward as a potential selective osteosarcoma therapy through the release of reactive species to the diseased site. To allow their translation to the clinics, it is crucial to show that the oxidative stress delivered by such hydrogels does not adversely affect healthy tissues. This is evaluated here by investigating the in vivo performance of a robocasted calcium phosphate cement infiltrated by a plasma‐treated hydrogel. The plasma‐treated composite implanted in a critical size bone defect of healthy rabbits revealed its safety, allowing equivalent bone ingrowth compared to the control scaffolds and to that of direct plasma treatment of the bone defect. This opens the door for using composite biomaterials containing plasma‐generated reactive species in bone therapies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/ppap.202200155 |
| الاتاحة: | http://dx.doi.org/10.1002/ppap.202200155 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ppap.202200155 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ppap.202200155 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.49F44D1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ppap.202200155 |
|---|