Academic Journal

Secretion of Recombinant Interleukin-22 by Engineered Lactobacillus reuteri Reduces Fatty Liver Disease in a Mouse Model of Diet-Induced Obesity

التفاصيل البيبلوغرافية
العنوان: Secretion of Recombinant Interleukin-22 by Engineered Lactobacillus reuteri Reduces Fatty Liver Disease in a Mouse Model of Diet-Induced Obesity
المؤلفون: Oh, Jee-Hwan, Schueler, Kathryn L., Stapleton, Donnie S., Alexander, Laura M., Yen, Chi-Liang Eric, Keller, Mark P., Attie, Alan D., van Pijkeren, Jan-Peter
المساهمون: Marco, Maria L., Food Research Institute, UW-Madison Graduate School, UW-Madison ICTR funded by Natl. Center for Advancing Translational Science, U.S. Department of Agriculture
المصدر: mSphere ; volume 5, issue 3 ; ISSN 2379-5042
بيانات النشر: American Society for Microbiology
سنة النشر: 2020
الوصف: In humans, nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease due to the increased prevalence of obesity. While treatment of NAFLD is often geared toward lifestyle changes, such as diet and exercise, the use of dietary supplements such as probiotics is underinvestigated. Here, we report that probiotic Lactobacillus reuteri reduces fatty liver in a mouse model of diet-induced obesity. This phenotype was further enhanced upon delivery of recombinant interleukin-22 by engineered Lactobacillus reuteri . These observations pave the road to a better understanding of probiotic mechanisms driving the reduction of diet-induced steatosis and to development of next-generation probiotics for use in the clinic. Ultimately, these studies may lead to rational selection of (engineered) probiotics to ameliorate fatty liver disease.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1128/msphere.00183-20
DOI: 10.1128/mSphere.00183-20
الاتاحة: http://dx.doi.org/10.1128/msphere.00183-20
https://journals.asm.org/doi/pdf/10.1128/mSphere.00183-20
Rights: https://creativecommons.org/licenses/by/4.0/ ; https://journals.asm.org/non-commercial-tdm-license
رقم الانضمام: edsbas.49E667DE
قاعدة البيانات: BASE
الوصف
DOI:10.1128/msphere.00183-20