Academic Journal
Assessing the associations between known genetic variants and substance use in people with HIV in the United States
| العنوان: | Assessing the associations between known genetic variants and substance use in people with HIV in the United States |
|---|---|
| المؤلفون: | Haas C.B., Jordahl K.M., Nance R.M., Whitney B.M., Wang L., Delaney J.A.C., Ruderman S., Jia T., Mathews W.C., Saag M.S., Lee S.A., Napravnik S., Jacobson J.M., Chander G., McCall E.M., Moore R.D., Mayer K.H., Mukherjee S., Lee W.J., Crane P.K., Crane H., Peter I., Lindström S. |
| المصدر: | PLoS ONE, 18(10-Oct) |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2023 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Human immunodeficiency virus infected patient, drug dependence, outcome assessment, adult, prevalence, gene frequency, genomic DNA, United States, substance use, female, male, genetic variability, single nucleotide polymorphism, HIV Infections, genetics, cannabis, Smoking, longitudinal study, major clinical study, alcohol, Ethanol, Human immunodeficiency virus infection, genome-wide association study, tobacco, cannabis use, DNA methylation, Humans, cigarette smoking, gene expression, drinking behavior |
| الوصف: | Background The prevalence of substance use in people with HIV (PWH) in the United States is higher than in the general population and is an important driver of HIV-related outcomes. We sought to assess if previously identified genetic associations that contribute to substance use are also observed in a population of PWH. Methods We performed genome-wide association studies (GWAS) of alcohol, smoking, and cannabis use phenotypes in a multi-ancestry population of 7,542 PWH from the Center for AIDS Research Network of Integrated Clinical Systems (CNICS). We conducted multi-ancestry GWAS for individuals of African (n = 3,748), Admixed American (n = 1,334), and European (n = 2,460) ancestry. Phenotype data were self-reported and collected using patient reported outcomes (PROs) and three questions from AUDIT-C, an alcohol screening tool. We analyzed nine phenotypes: 1) frequency of alcohol consumption, 2) typical number of drinks on a day when drinking alcohol, 3) frequency of five or more alcoholic drinks in a 30-day period, 4) smoking initiation, 5) smoking cessation, 6) cigarettes per day, 7) cannabis use initiation, 8) cannabis use cessation, 9) frequency of cannabis use during the previous 30 days. For each phenotype we considered a) variants previously identified as associated with a substance use trait and b) novel associations. Results We observed evidence for effects of previously reported single nucleotide polymorphisms (SNPs) related to alcohol (rs1229984, p = 0.001), tobacco (rs11783093, p = 2.22E-4), and cannabis use (rs2875907, p = 0.005). We also report two novel loci (19p13.2, p = 1.3E-8; and 20p11.21, p = 2.1E-8) associated with cannabis use cessation. Conclusions Our analyses contribute to understanding the genetic bases of substance use in a population with relatively higher rates of use compared to the general population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.17615/3s2d-2j41; https://cdr.lib.unc.edu/downloads/9306t958r?file=thumbnail; https://cdr.lib.unc.edu/downloads/9306t958r |
| DOI: | 10.17615/3s2d-2j41 |
| الاتاحة: | https://doi.org/10.17615/3s2d-2j41 https://cdr.lib.unc.edu/downloads/9306t958r?file=thumbnail https://cdr.lib.unc.edu/downloads/9306t958r |
| رقم الانضمام: | edsbas.49D39391 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/3s2d-2j41 |
|---|