Image
CypB KO mice and not CypA KO mice develop less liver fibrosis after administration of CCl 4 .
| العنوان: | CypB KO mice and not CypA KO mice develop less liver fibrosis after administration of CCl 4 . |
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| المؤلفون: | Winston T. Stauffer, Asha Z. Goodman, Michael Bobardt, Daren R. Ure, Robert T. Foster, Philippe Gallay |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Medicine, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Infectious Diseases, Chemical Sciences not elsewhere classified, tnf &# 945, stained liver sections, observed therapeutic effects, human liver fibrosis, essential cellular functions, div >< p, nash disease progression, mice without cypb, mice without cypa, decreased disease, specific role, responsible isoform, reliably replicated, prolyl isomerases, previously reported, picrosirius red, novel avenue, induced nash, high sugar, drug treatments, diverse family, determine whether |
| الوصف: | WT, CypB KO, and CypA KO mice were administered CCl 4 twice weekly via intraperitoneal (IP) injection for twenty weeks. WT and CypA mice developed significant interlobular branching fibrosis, as determined by histological analysis of picrosirius red-stained liver tissue sections. CypB KO mice however, displayed significantly less stained area relative to other groups. The area of stained tissue relative to the total area was quantified with ImageJ software over several fields per sample. Representative images are shown here. *** p≤0.001 significance between a condition and WT control by unpaired students t-test. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/CypB_KO_mice_and_not_CypA_KO_mice_develop_less_liver_fibrosis_after_administration_of_CCl_sub_4_sub_/25326770 |
| DOI: | 10.1371/journal.pone.0298211.g001 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0298211.g001 https://figshare.com/articles/figure/CypB_KO_mice_and_not_CypA_KO_mice_develop_less_liver_fibrosis_after_administration_of_CCl_sub_4_sub_/25326770 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.49CC7010 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0298211.g001 |
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