Academic Journal
SMN affects membrane remodelling and anchoring of the protein synthesis machinery
| العنوان: | SMN affects membrane remodelling and anchoring of the protein synthesis machinery |
|---|---|
| المؤلفون: | Gabanella, F, Pisani, C, Borreca, A, Farioli Vecchioli, S, Ciotti, Mt, Ingegnere, T, Onori, A, Ammassari Teule, M, Corbi, N, Monaco, L, Passananti, C, Di Certo, Mg, CANU, NADIA |
| المساهمون: | Gabanella, F, Pisani, C, Borreca, A, Farioli Vecchioli, S, Ciotti, M, Ingegnere, T, Onori, A, Ammassari Teule, M, Corbi, N, Canu, N, Monaco, L, Passananti, C, Di Certo, M |
| سنة النشر: | 2016 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Actin filament, Local translation, Membrane remodelling, SMN, Settore BIO/09 - FISIOLOGIA |
| الوصف: | Disconnection between membrane signalling and actin networks can have catastrophic effects depending on cell size and polarity. The survival motor neuron (SMN) protein is ubiquitously involved in assembly of spliceosomal small nuclear ribonucleoprotein particles. Other SMN functions could, however, affect cellular activities driving asymmetrical cell surface expansions. Genes able to mitigate SMN deficiency operate within pathways in which SMN can act, such as mRNA translation, actin network and endocytosis. Here, we found that SMN accumulates at membrane protrusions during the dynamic rearrangement of the actin filaments. In addition to localization data, we show that SMN interacts with caveolin-1, which mediates anchoring of translation machinery components. Importantly, SMN deficiency depletes the plasma membrane of ribosomes, and this correlates with the failure of fibroblasts to extend membrane protrusions. These findings strongly support a relationship between SMN and membrane dynamics. We propose that SMN could assembly translational platforms associated with and governed by the plasma membrane. This activity could be crucial in cells that have an exacerbated interdependence of membrane remodelling and local protein synthesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/26743087; info:eu-repo/semantics/altIdentifier/wos/WOS:000370240900014; volume:129; issue:4; firstpage:804; lastpage:816; numberofpages:13; journal:JOURNAL OF CELL SCIENCE; http://hdl.handle.net/2108/163757; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84961218545 |
| DOI: | 10.1242/jcs.176750 |
| الاتاحة: | http://hdl.handle.net/2108/163757 https://doi.org/10.1242/jcs.176750 |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.49CABF3C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1242/jcs.176750 |
|---|