Academic Journal
Astrocyte-neuronal network interplay is disrupted in Alzheimer's disease mice
| العنوان: | Astrocyte-neuronal network interplay is disrupted in Alzheimer's disease mice |
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| المؤلفون: | Lines, J., Baraibar, A.M., Fang, C., Martín, E.D., Aguilar, J., Lee, M.K., Araque, Alfonso, Kofuji, P. |
| المساهمون: | Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), National Institute of Neurological Disorders and Stroke (US), National Institute of Mental Health (US), National Institute on Aging (US), National Institute on Drug Abuse (US) |
| بيانات النشر: | John Wiley & Sons |
| سنة النشر: | 2022 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Alzheimer's disease, APP/PS1, astrocyte, astrogliosis, beta amyloid, cortex |
| الوصف: | Alzheimer's disease (AD) is associated with senile plaques of beta-amyloid (Aβ) that affect the function of neurons and astrocytes. Brain activity results from the coordinated function of neurons and astrocytes in astroglial-neuronal networks. However, the effects of Aβ on astroglial and neuronal network function remains unknown. Simultaneously monitoring astrocyte calcium and electric neuronal activities, we quantified the impact of Aβ on sensory-evoked cortical activity in a mouse model of AD. At rest, cortical astrocytes displayed spontaneous hyperactivity that was related to Aβ density. Sensory-evoked astrocyte responsiveness was diminished in AD mice, depending on the density and distance of Aβ, and the responses showed altered calcium dynamics. Hence, astrocytes were spontaneously hyperactive but hypo-responsive to sensory stimulation. Finally, AD mice showed sensory-evoked electrical cortical hyperresponsiveness associated with altered astrocyte-neuronal network interplay. Our findings suggest dysfunction of astrocyte networks in AD mice may dysregulate cortical electrical activity and contribute to cognitive decline. ; Ayudas para la Movilidad de Investigadores, Grant/Award Number: BA15/00078; Ministerio de Ciencia, Innovacion y Universidades, Grant/Award Number: BFU2017-88393-P; Ministerio de Economía y Competitividad, Grant/Award Number: BFU2016-80665-P; National Institute of Mental Health, Grant/Award Number: R01MH119355; National Institute of Neurological Disorders and Stroke, Grant/ Award Number: R01NS097312; National Institute on Aging, Grant/Award Numbers: 1F31AG057155, RF1AG062135; National Institute on Drug Abuse, Grant/Award Number: R01DA048822; Salvador de Madariaga Program, Grant/Award Number: PRX19/00646 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1098-1136 |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO//BA15%2F00078/ES/BA15%2F00078/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-88393-P/ES/MECANISMOS SINAPTICOS Y CELULARES QUE SUBYACEN A LAS ADAPTACIONES FUNCIONALES DEL SISTEMA NERVIOSO DURANTE LA LACTANCIA/; Publisher's version; http://dx.doi.org/10.1002/glia.24112; Sí; Glia 70: 368- 378 (2022); http://hdl.handle.net/10261/275039; http://dx.doi.org/10.13039/501100003329; http://dx.doi.org/10.13039/100000065 |
| DOI: | 10.1002/glia.24112 |
| DOI: | 10.13039/501100003329 |
| DOI: | 10.13039/100000065 |
| الاتاحة: | http://hdl.handle.net/10261/275039 https://doi.org/10.1002/glia.24112 https://doi.org/10.13039/501100003329 https://doi.org/10.13039/100000065 |
| Rights: | open |
| رقم الانضمام: | edsbas.49BFDA90 |
| قاعدة البيانات: | BASE |
| تدمد: | 10981136 |
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| DOI: | 10.1002/glia.24112 |