التفاصيل البيبلوغرافية
| العنوان: |
Fibrillary Glomerulonephritis in a Patient with a History of Vulvar Squamous Cell Carcinoma |
| المؤلفون: |
Jagadish, Ashwin, Vedantam, Venkata, Vedantam, Neethu, Magacha, Hezborn |
| المصدر: |
Appalachian Student Research Forum |
| بيانات النشر: |
Digital Commons @ East Tennessee State University |
| سنة النشر: |
2023 |
| المجموعة: |
Digital Commons @ East Tennessee State University |
| مصطلحات موضوعية: |
fibrillary glomerulonephritis, vulvar squamous cell carcinoma, dnajb9, Cancer or Carcinogenesis |
| الوصف: |
Fibrillary glomerulonephritis (FGN) is a rare disease identified in less than one percent of native kidney biopsy. FGN is characterized by hematuria, edema, renal insufficiency, and high-grade proteinuria. Renal biopsy results typically demonstrate deposition of randomly-arranged fibrils within the capillary wall or mesangium. Positive staining with DnaJ Heat Shock Protein Family Member B9 (DNAJB9) is considered diagnostic. Associations include malignancy, hepatitis C, dysproteinemia, autoimmune disorders, and diabetes mellitus. To our knowledge, this is the first case demonstrating association between fibrillary glomerulonephritis and vulvar squamous cell carcinoma. A 66-year-old year old Caucasian female presented to the emergency department for worsening renal injury. She was diagnosed with vulvar squamous cell carcinoma 5 years prior and underwent radical excision with inguinal lymphadenectomy and CO2 laser treatment. Over the years, she had multiple relapses and received wide local excision and adjuvant radiation, with the last treatment involving radiation being 2.5 years before admission. The patient had a recently identified non-malignant vulvar lesion at the time of admission, which was found to be lichen sclerosus et atrophicus. She was found to have renal dysfunction and nephrotic range proteinuria; her creatinine was 2.84 mg/dL (normal range 0.60–1.10 mg/dL), BUN 33 mg/dL (normal range 6–20 mg/dL), urine protein:creatinine ratio 3.9 mg/g (normal range < 0.15 mg/g). She was started on pulse dose methylprednisolone of 500 mg daily, but her creatinine worsened, necessitating renal biopsy. Renal biopsy findings indicated mesangial expansion and randomly-arranged non-branching fibril deposition. Glomerular immunofluorescence indicated positive staining for IgA, IgG, and DNAJB9. These findings confirmed the diagnosis of fibrillary glomerulonephritis. Screening for associations – coexistent malignancies, hepatitis C, multiple myeloma, and autoimmune disorders – was negative. The patient was started on ... |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| Relation: |
https://dc.etsu.edu/asrf/2023/schedule/194 |
| الاتاحة: |
https://dc.etsu.edu/asrf/2023/schedule/194 |
| رقم الانضمام: |
edsbas.49A743F9 |
| قاعدة البيانات: |
BASE |