Academic Journal

Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury

التفاصيل البيبلوغرافية
العنوان: Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury
المؤلفون: Veselina Petrova, Bart Nieuwenhuis, James W. Fawcett, Richard Eva
المصدر: International Journal of Molecular Sciences; Volume 22; Issue 4; Pages: 1798
بيانات النشر: Multidisciplinary Digital Publishing Institute
سنة النشر: 2021
المجموعة: MDPI Open Access Publishing
مصطلحات موضوعية: axon growth, axon regeneration, inter-organelle membrane contact sites, organelles
جغرافية الموضوع: agris
الوصف: Investigating the molecular mechanisms governing developmental axon growth has been a useful approach for identifying new strategies for boosting axon regeneration after injury, with the goal of treating debilitating conditions such as spinal cord injury and vision loss. The picture emerging is that various axonal organelles are important centers for organizing the molecular mechanisms and machinery required for growth cone development and axon extension, and these have recently been targeted to stimulate robust regeneration in the injured adult central nervous system (CNS). This review summarizes recent literature highlighting a central role for organelles such as recycling endosomes, the endoplasmic reticulum, mitochondria, lysosomes, autophagosomes and the proteasome in developmental axon growth, and describes how these organelles can be targeted to promote axon regeneration after injury to the adult CNS. This review also examines the connections between these organelles in developing and regenerating axons, and finally discusses the molecular mechanisms within the axon that are required for successful axon growth.
نوع الوثيقة: text
وصف الملف: application/pdf
اللغة: English
Relation: Molecular Neurobiology; https://dx.doi.org/10.3390/ijms22041798
DOI: 10.3390/ijms22041798
الاتاحة: https://doi.org/10.3390/ijms22041798
Rights: https://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.49A0B321
قاعدة البيانات: BASE