Academic Journal
BONSAI-2 study: Nivolumab as therapeutic option after cabozantinib failure in metastatic collecting duct carcinoma patients
| العنوان: | BONSAI-2 study: Nivolumab as therapeutic option after cabozantinib failure in metastatic collecting duct carcinoma patients |
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| المؤلفون: | Buti, Sebastiano, Trentini, Francesca, Sepe, Pierangela, Claps, Melanie, Isella, Luca, Verzoni, Elena, Procopio, Giuseppe |
| المصدر: | Tumori Journal ; volume 109, issue 4, page 418-423 ; ISSN 0300-8916 2038-2529 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2022 |
| الوصف: | Background: The BONSAI phase II trial recently demonstrated the activity of cabozantinib in metastatic collecting duct patients. The outcomes of patients in this setting treated with immunotherapy as second-line is unknown. The aim of the present report was to describe outcomes of patients enrolled in the BONSAI trial that received nivolumab as second-line treatment. Material and methods: We describe the oncological outcomes in terms of overall response rate, progression-free survival, overall survival and safety. We excluded patients that did not receive any second-line treatment or were treated with agents other than nivolumab. Results: We identified five patients of whom one was excluded due to lack of data. Three patients obtained clinical benefit (one partial response, two stable disease); the second-line progression-free survival (nivolumab) ranged from 2.8 to 19.9 months to and second-line overall survival ranged from 5.1 to 26.5 months. No new safety signals were observed. Conclusions: Nivolumab may be considered as second-line therapy option after cabozantinib failure in selected metastatic collecting duct carcinoma patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/03008916221141483 |
| الاتاحة: | http://dx.doi.org/10.1177/03008916221141483 http://journals.sagepub.com/doi/pdf/10.1177/03008916221141483 http://journals.sagepub.com/doi/full-xml/10.1177/03008916221141483 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.499DC8D1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/03008916221141483 |
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