التفاصيل البيبلوغرافية
| العنوان: |
Enantioselective Construction of 1 H ‑Isoindoles Containing Tri- and Difluoromethylated Quaternary Stereogenic Centers via Palladium-Catalyzed C–H Bond Imidoylation |
| المؤلفون: |
Jian Wang (5901), Lianjie Li (7247786), Minxue Chai (11466472), Shumin Ding (8849237), Jing Li (10611), Yongjia Shang (556386), Haixia Zhao (414895), Dan Li (106345), Qiang Zhu (188733) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Biotechnology, Developmental Biology, Infectious Diseases, reactions proceeded smoothly, offering rapid access, low catalyst loadings, difluoroethylated isocyanides acted, allene insertion cascade, intermolecular enantioselective synthesis, enantioselective construction, tethered bis, reaction efficiency, powerful precursors, mild conditions, high enantioselectivities, heterocyclic scaffolds, h <, good yields, fluoroalkyl group, diverse c1, diaryl tri, crucial role, >- isoindoles |
| الوصف: |
An intermolecular enantioselective synthesis of 1 H -isoindoles containing tri- and difluoromethylated quaternary stereogenic centers through a palladium-catalyzed desymmetric C–H bond imidoylation has been developed. α,α-Diaryl tri- and difluoroethylated isocyanides acted as powerful precursors of chiral 1 H -isoindoles, in which the fluoroalkyl group was proven to play a crucial role in both the stereochemistry and reaction efficiency. In addition, an allene insertion cascade was realized, offering rapid access to diverse C1-tethered bis-heterocyclic scaffolds with good yields and high enantioselectivities. The reactions proceeded smoothly under mild conditions with low catalyst loadings. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Enantioselective_Construction_of_1_i_H_i_Isoindoles_Containing_Tri-_and_Difluoromethylated_Quaternary_Stereogenic_Centers_via_Palladium-Catalyzed_C_H_Bond_Imidoylation/16660222 |
| DOI: |
10.1021/acscatal.1c03682.s001 |
| الاتاحة: |
https://doi.org/10.1021/acscatal.1c03682.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.49657601 |
| قاعدة البيانات: |
BASE |