Academic Journal

Sleep Alterations in a Mouse Model of Spinocerebellar Ataxia Type 3

التفاصيل البيبلوغرافية
العنوان: Sleep Alterations in a Mouse Model of Spinocerebellar Ataxia Type 3
المؤلفون: Maria-Efstratia Tsimpanouli, Anjesh Ghimire, Anna J. Barget, Ridge Weston, Henry L. Paulson, Maria do Carmo Costa, Brendon O. Watson
المصدر: Cells; Volume 11; Issue 19; Pages: 3132
بيانات النشر: Multidisciplinary Digital Publishing Institute
سنة النشر: 2022
المجموعة: MDPI Open Access Publishing
مصطلحات موضوعية: polyglutamine, ataxin-3, sleep, EEG, beta-oscillations
الوصف: Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder showing progressive neuronal loss in several brain areas and a broad spectrum of motor and non-motor symptoms, including ataxia and altered sleep. While sleep disturbances are known to play pathophysiologic roles in other neurodegenerative disorders, their impact on SCA3 is unknown. Using spectrographic measurements, we sought to quantitatively characterize sleep electroencephalography (EEG) in SCA3 transgenic mice with confirmed disease phenotype. We first measured motor phenotypes in 18–31-week-old homozygous SCA3 YACMJD84.2 mice and non-transgenic wild-type littermate mice during lights-on and lights-off periods. We next implanted electrodes to obtain 12-h (zeitgeber time 0-12) EEG recordings for three consecutive days when the mice were 26–36 weeks old. EEG-based spectroscopy showed that compared to wild-type littermates, SCA3 homozygous mice display: (i) increased duration of rapid-eye movement sleep (REM) and fragmentation in all sleep and wake states; (ii) higher beta power oscillations during REM and non-REM (NREM); and (iii) additional spectral power band alterations during REM and wake. Our data show that sleep architecture and EEG spectral power are dysregulated in homozygous SCA3 mice, indicating that common sleep-related etiologic factors may underlie mouse and human SCA3 phenotypes.
نوع الوثيقة: text
وصف الملف: application/pdf
اللغة: English
Relation: Cells of the Nervous System; https://dx.doi.org/10.3390/cells11193132
DOI: 10.3390/cells11193132
الاتاحة: https://doi.org/10.3390/cells11193132
Rights: https://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.495B4A91
قاعدة البيانات: BASE