Academic Journal
Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection
| العنوان: | Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection |
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| المؤلفون: | Chukwuanukwu, Rebecca C., Onyenekwe, Charles C., Martinez-Pomares, Luisa, Flynn, Robin J., Singh, Sonali, Amilo, Grace I., Agbakoba, Nneka R., Okoye, Jude O. |
| بيانات النشر: | Wiley |
| سنة النشر: | 2016 |
| المجموعة: | University of Nottingham: Repository@Nottingham |
| مصطلحات موضوعية: | co-infection, cytokines, HIV, malaria, tuberculosis |
| الوصف: | Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African region. TB is a leading cause of death among HIV-positive patients and co-infection with HIV and TB has been described as a syndemic. In view of the overlapping epidemiology of these diseases, it is important to understand the dynamics of the immune response to TB in the context of co-infection. We investigated the cytokine response to purified protein derivative (PPD) in peripheral blood mononuclear cells from TB patients co-infected with HIV or malaria and compared it to that of malaria- and HIV-free TB patients. A total of 231 subjects were recruited for this study and classified into six groups; untreated TB-positive, TB positive subjects on TB drugs, TB- and HIV-positive, TB- and malaria-positive, latent TB and apparently healthy control subjects. Our results demonstrate maintenance of interferon (IFN)-γ production in HIV and malaria co-infected TB patients in spite of lower CD4 counts in the HIV-infected cohort. Malaria co-infection caused an increase in the production of the T helper type 2 (Th2)-associated cytokine interleukin (IL)-4 and the anti-inflammatory cytokine IL-10 in PPD-stimulated cultures. These results suggest that malaria co-infection diverts immune response against M. tuberculosis towards a Th-2/anti-inflammatory response which might have important consequences for disease progression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://nottingham-repository.worktribe.com/output/822210; Clinical and Experimental Immunology; Volume 187; Issue 2 |
| DOI: | 10.1111/cei.12861 |
| الاتاحة: | https://doi.org/10.1111/cei.12861 https://nottingham-repository.worktribe.com/file/822210/1/Chukwuanukwu_et_al-2016-Clinical__Experimental_Immunology.pdf https://nottingham-repository.worktribe.com/output/822210 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.494FEADD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cei.12861 |
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