Academic Journal
Tissue architecture in tumor initiation and progression.
| العنوان: | Tissue architecture in tumor initiation and progression. |
|---|---|
| المؤلفون: | Almagro, J, Messal, HA, Elosegui-Artola, A, van Rheenen, J, Behrens, A |
| المساهمون: | Behrens, Axel |
| بيانات النشر: | CELL PRESS |
| سنة النشر: | 2022 |
| المجموعة: | The Institute of Cancer Research (ICR): Publications Repository |
| مصطلحات موضوعية: | Stromal Cells, Humans, Neoplasms, Cell Transformation, Neoplastic, Tumor Microenvironment |
| الوصف: | The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the cancer cells, the host tissue, and the molecular and cellular microenvironment modulate the morphology of the tumor and its malignant potential through mechanical, biochemical, genetic, and epigenetic cues. Recent studies have investigated how tissue architecture influences cancer biology from tumor initiation and progression to distant metastatic seeding and response to therapy. With a focus on carcinoma, the most common type of cancer, this review discusses the latest discoveries on how tumor architecture is built and how tissue morphology affects the biology and progression of cancer cells. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; 505; application/pdf |
| اللغة: | English |
| تدمد: | 2405-8033 2405-8025 |
| Relation: | Trends in cancer, 2022, 8 (6), pp. 494 - 505; https://repository.icr.ac.uk/handle/internal/5158 |
| DOI: | 10.1016/j.trecan.2022.02.007 |
| الاتاحة: | https://repository.icr.ac.uk/handle/internal/5158 https://doi.org/10.1016/j.trecan.2022.02.007 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.4948D87F |
| قاعدة البيانات: | BASE |
| تدمد: | 24058033 24058025 |
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| DOI: | 10.1016/j.trecan.2022.02.007 |