التفاصيل البيبلوغرافية
| العنوان: |
A Visible-Light-Sensitive Caged Serotonin |
| المؤلفون: |
Cabrera, R., Filevich, O., García-Acosta, B., Athilingam, J., Bender, K.J., Poskanzer, K.E., Etchenique, R. |
| المجموعة: |
Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires) |
| مصطلحات موضوعية: |
neurophysiology, phototriggers, Ruthenium complex, serotonin, ruthenium, animal cell, Article, light absorption, mouse, nerve cell excitability, nonhuman, pH, photochemistry, photolysis, photosensitivity, priority journal, proton nuclear magnetic resonance, pyramidal nerve cell, quantum yield, animal, chemistry, drug effects, light, metabolism, nerve cell, prefrontal cortex, Animals, Mice, Neurons |
| الوصف: |
Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons. © 2017 American Chemical Society. ; Fil:Filevich, O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. ; Fil:García-Acosta, B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. ; Fil:Etchenique, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
| نوع الوثيقة: |
journal/newspaper |
| اللغة: |
unknown |
| Relation: |
http://hdl.handle.net/20.500.12110/paper_19487193_v8_n5_p1036_Cabrera |
| الاتاحة: |
https://hdl.handle.net/20.500.12110/paper_19487193_v8_n5_p1036_Cabrera |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/2.5/ar |
| رقم الانضمام: |
edsbas.49330662 |
| قاعدة البيانات: |
BASE |