Academic Journal
Anti‐inflammatory actions of an N‐terminal peptide from human lipocortin 1
| العنوان: | Anti‐inflammatory actions of an N‐terminal peptide from human lipocortin 1 |
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| المؤلفون: | Cirino, G., Cicala, C., Sorrentino, L., Ciliberto, G., Arpaia, G., Perretti, M., Flower, R.J. |
| المصدر: | British Journal of Pharmacology ; volume 108, issue 3, page 573-574 ; ISSN 0007-1188 1476-5381 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1993 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | An acetylated polypeptide corresponding to residues 2–26 of human lipocortin 1 was synthesized and the anti‐inflammatory activity assessed in three models of acute inflammation in rat and mouse. In the carrageenin rat paw oedema test, the peptide produced a maximal inhibition of approximately 41% at the 3 h time point with a 10 μg dose. When rat paw oedema was induced by the injection of venom phospholipase A 2 , the peptide produced a significant inhibition (31%) at the top dose of 20 μg per paw. In the mouse air‐pouch model, systemic treatment with the peptide produced a dramatic reduction in cytokine‐induced leukocyte migration with an ID 50 of approximately 40 μg per mouse. The N‐terminal peptide 2–26 shares the actions of lipocortin 1 in these acute models of inflammation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1476-5381.1993.tb12843.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1476-5381.1993.tb12843.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.1993.tb12843.x https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1993.tb12843.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.491F192F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1476-5381.1993.tb12843.x |
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