التفاصيل البيبلوغرافية
| العنوان: |
Visualizing the Underlying Signaling Pathway Related to Nitric Oxide and Glutathione in Cardiovascular Disease Therapy by a Sequentially Activated Fluorescent Probe |
| المؤلفون: |
Xiao-Xiao Chen (3321351), Li-Ya Niu (1634431), Qing-Zheng Yang (1273215) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Virology, Computational Biology, Chemical Sciences not elsewhere classified, probe exhibits turn-on fluorescence, NO-induced GSH upregulation, Signaling Pathway Related, pathway, disease therapy, Cardiovascular Disease Therapy |
| الوصف: |
Clarifying the signaling pathway associated with nitric oxide (NO) and glutathione (GSH) in cardiovascular disease therapy is important for understanding its physiological and pathological processes but is challenging due to the lack of efficient analytical techniques. Herein, we report a BODIPY-based fluorescent probe for recognition of NO and GSH in sequence with high sensitivity and selectivity. The probe exhibits turn-on fluorescence triggered by NO, followed by red-shifted emission in the presence of GSH. The sequentially activated mechanism allows the visualization of NO-induced GSH upregulation in drug-treated endothelial cells and zebrafish for the first time, revealing a signal pathway during the therapy. We hope that it can be used as a convenient and efficient tool for the study of the interplay between NO and GSH and for the screening of effective drugs for cardiovascular disease therapy. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Visualizing_the_Underlying_Signaling_Pathway_Related_to_Nitric_Oxide_and_Glutathione_in_Cardiovascular_Disease_Therapy_by_a_Sequentially_Activated_Fluorescent_Probe/14035740 |
| DOI: |
10.1021/acs.analchem.0c04754.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.analchem.0c04754.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.4902FF36 |
| قاعدة البيانات: |
BASE |