التفاصيل البيبلوغرافية
| العنوان: |
Discovery of an Unexpected 1,4-Oxazepine-Linked seco -Fluostatin Heterodimer by Inactivation of the Oxidoreductase-Encoding Gene flsP |
| المؤلفون: |
Chunshuai Huang (1490785), Chunfang Yang (1490788), Wenjun Zhang (685002), Liping Zhang (177396), Yiguang Zhu (340294), Changsheng Zhang (1450165) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Genetics, Physiology, Immunology, Marine Biology, Space Science, Chemical Sciences not elsewhere classified, fluostatin T, biosynthetic considerations, mass spectrometry, isoxazolinone ring, X-ray diffraction analysis, Fluostatin W, Fluostatin Heterodimer, Oxidoreductase-Encoding Gene flsP F., fluostatin heterodimer difluostatin, flavin adenine dinucleotide-binding., seco, fluostatin skeleton, fluostatin-related derivatives |
| الوصف: |
Fluostatins belong to the atypical angucyclinone aromatic polyketides featuring a distinctive tetracyclic benzo[ a ]fluorene skeleton. To understand the formation of the heavily oxidized A-ring in fluostatins, a flavin adenine dinucleotide-binding oxidoreductase-encoding gene flsP was inactivated, leading to the production of an unprecedented 1,4-oxazepine-linked seco -fluostatin heterodimer difluostatin I ( 7 ) and five new fluostatin-related derivatives, fluostatins T–X ( 8 – 12 ). Their structures were elucidated by mass spectrometry, nuclear magnetic resonance, X-ray diffraction analysis, and biosynthetic considerations. Difluostatin I ( 7 ) represents the first example with an A-ring-cleaved 3′,4′- seco -fluostatin skeleton. The absolute configuration of fluostatin T ( 8 ) was determined by X-ray diffraction analysis. Fluostatin W ( 11 ) contains an uncommon isoxazolinone ring. These findings highlight the structural diversity of fluostatins. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Discovery_of_an_Unexpected_1_4-Oxazepine-Linked_i_seco_i_-Fluostatin_Heterodimer_by_Inactivation_of_the_Oxidoreductase-Encoding_Gene_i_flsP_i_/15161374 |
| DOI: |
10.1021/acs.jnatprod.1c00461.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.jnatprod.1c00461.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.48E20006 |
| قاعدة البيانات: |
BASE |