Academic Journal
Socioeconomic representativeness of Australian, Canadian and British cohorts from the paediatric diabetes AdDIT study: comparisons to regional and national data.
| العنوان: | Socioeconomic representativeness of Australian, Canadian and British cohorts from the paediatric diabetes AdDIT study: comparisons to regional and national data. |
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| المؤلفون: | Mahmud, Farid H, Clarke, Antoine BM, Elia, Yesmino, Curtis, Jacqueline, Benitez-Aguirre, Paul, Cameron, Fergus J, Chiesa, Scott T, Clarson, Cheril, Couper, Jennifer J, Craig, Maria E, Dalton, R Neil, Daneman, Denis, Davis, Elizabeth A, Deanfield, John E, Donaghue, Kim C, Jones, Timothy W, Marshall, Sally M, Neil, Andrew, Marcovecchio, M Loredana |
| بيانات النشر: | Springer Science and Business Media LLC //doi.org/10.1186/s12916-023-03222-w BMC Med |
| سنة النشر: | 2023 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Clinical trial, Deprivation, Marginalization, Multicenter trials, Paediatric, Socioeconomic status, Type 1 diabetes, Adolescent, Humans, Australia, Canada, Clinical Trials as Topic, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Retrospective Studies, Socioeconomic Factors |
| الوصف: | Acknowledgements: The authors want to acknowledge persons with type 1 diabetes for their support and participation in the AdDIT study. We would also like to recognize and acknowledge the invaluable contributions and leadership of Prof. David Dunger as part of the AdDIT study. ; Funder: Can-SOLVE CKD ; Funder: Canadian Institute of Health Research – Strategies for Patient Oriented Research ; Funder: Juvenile Diabetes Research Foundation Canada; doi: http://dx.doi.org/10.13039/100009881 ; BACKGROUND: Given limited data regarding the involvement of disadvantaged groups in paediatric diabetes clinical trials, this study aimed to evaluate the socioeconomic representativeness of participants recruited into a multinational clinical trial in relation to regional and national type 1 diabetes reference populations. METHODS: Retrospective, cross-sectional evaluation of a subset of adolescent type 1 diabetes cardiorenal intervention trial (AdDIT) participants from Australia (n = 144), Canada (n = 312) and the UK (n = 173). Validated national measures of deprivation were used: the Index of Relative Socioeconomic Disadvantage (IRSD) 2016 (Australia), the Material Resources (MR) dimension of the Canadian Marginalisation index 2016 (Canada) and the Index of Multiple Deprivation (IMD) 2015 (UK). Representativeness was assessed by comparing the AdDIT cohort's distribution of deprivation quintiles with that of the local paediatric type 1 diabetes population (regional), and the broader type 1 diabetes population for which the trial's intervention was targeted (national). RESULTS: Recruited study cohorts from each country had higher proportions of participants with higher SES, and significant underrepresentation of lower SES, in relation to their national references. The socioeconomic make-up in Australia mirrored that of the regional population (p = 0.99). For Canada, the 2nd least deprived (p = 0.001) and the most deprived quintiles (p < 0.001) were over- and under-represented relative to the regional reference, while the UK ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/xml |
| اللغة: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/362633 |
| الاتاحة: | https://www.repository.cam.ac.uk/handle/1810/362633 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.48D9FA89 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |