Academic Journal
Management of adult-onset Still's disease with interleukin-1 inhibitors: Evidence- And consensus-based statements by a panel of Italian experts
| العنوان: | Management of adult-onset Still's disease with interleukin-1 inhibitors: Evidence- And consensus-based statements by a panel of Italian experts |
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| المؤلفون: | Colafrancesco, Serena, Manara, Maria, Bortoluzzi, Alessandra, Serban, Teodora, Bianchi, Gerolamo, Cantarini, Luca, Ciccia, Francesco, Dagna, Lorenzo, Govoni, Marcello, Montecucco, Carlomaurizio, Priori, Roberta, Ravelli, Angelo, Sfriso, Paolo, Sinigaglia Luigi, Stefano Alivernini, Elena Baldissera, Elena Bartoloni, Alvise Berti, Serena Bugatti, Dario Camellino, Daniele Cammelli, Roberto Caporali, Francesco Caso, Elena Cavallaro, Giulio Cavalli, Michele Colaci, Luisa Costa, Gerardo di Scala, Giacomo Emmi, Micol Frassi, Roberto Gerli, Roberto Giacomelli, Elisa Gremese, Florenzo Iannone, Giovanni Lapadula, Lorenzo Leveghi, Giuseppe Lopalco, Raffaele Manna, Daniela Marotto, Alessandro Mathieu, Rossella Neri, Isabella Patisso, Matteo Piga, Leonardo Punzi, Micol Romano, Piero Ruscitti, Carlo Salvarani, Raffaele Scarpa, Rossana Scrivo, Rosaria Talarico, Elena Verrecchia, Ombretta Viapiana, Antonio Vitale, Gianfranco Vitiello |
| المساهمون: | S. Colafrancesco, M. Manara, A. Bortoluzzi, T. Serban, G. Bianchi, L. Cantarini, F. Ciccia, L. Dagna, M. Govoni, C. Montecucco, R. Priori, A. Ravelli, P. Sfriso, L. Sinigaglia, A. Stefano, B. Elena, B. Alvise, B. Serena, C. Dario, C. Daniele, R.F. Caporali, C. Francesco, C. Elena, C. Giulio, C. Michele, C. Luisa, Gerardo di Scala, E. Giacomo, F. Micol, G. Roberto, G. Elisa, I. Florenzo, L. Giovanni, L. Lorenzo, L. Giuseppe, M. Raffaele, M. Daniela, M. Alessandro, N. Rossella, P. Isabella, P. Matteo, P. Leonardo, R. Micol, R. Piero, S. Carlo, S. Raffaele, S. Rossana, T. Rosaria, V. Elena, V. Ombretta, V. Antonio, V. Gianfranco |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2019 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Adult-onset Still's disease, Anakinra, Canakinumab, Interleukin-1, Rilonacept, Still's disease, Systemic juvenile idiopathic arthritis, Settore MED/16 - Reumatologia |
| الوصف: | Background: Adult-onset Still's disease (AOSD) is a rare inflammatory condition characterized by fever, rash, and arthritis. Because of its rarity, clinical trials are inherently small and often uncontrolled. Our objective was to develop recommendations for the use of interleukin (IL)-1 inhibitors in the management of patients with AOSD, based on the best evidence and expert opinion. Methods: A panel of 10 experts (9 rheumatologists and 1 pediatrician) was established. The first step was dedicated to a comprehensive literature review and development of statements. Two separate literature searches were performed on the MEDLINE (Pubmed), EMBASE, and BIOSIS databases through April 2018 to identify (1) differences and similarities between AOSD and pediatric Still's disease (systemic juvenile idiopathic arthritis [SJIA]) and (2) the efficacy and safety of IL-1 inhibitors in AOSD treatment. In the second step, the statements were submitted in a Delphi process to a panel of 67 rheumatologists. Consensus threshold was set at 66%: positive, > 66% of voters selected scores 3 to 5; negative, > 66% of voters selected scores 1 or 2. In the third step, the voting results were analyzed, and the statements were finalized. Results: Eleven statements were developed. Forty-six of 67 rheumatologists (72%) participated in the Delphi process. A positive consensus was reached after the first round of voting and was full (> 95%) on the majority of statements. A large consensus was achieved in considering AOSD and SJIA as the same disease. The use of anti-IL-1 therapies in refractory patients was considered quite safe and effective both as the first and as a subsequent line of biologic treatment, especially in systemic patients. Because of the lack of head-to-head comparisons, a different profile of efficacy among IL-1 inhibitors could not be established. There was a large consensus that failure of the first IL-1 inhibitor does not preclude response to another one. The lack of studies comparing early versus late treatment did ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31829244; info:eu-repo/semantics/altIdentifier/wos/WOS:000509120900001; volume:21; issue:1; firstpage:1; lastpage:21; numberofpages:21; journal:ARTHRITIS RESEARCH & THERAPY; https://hdl.handle.net/2434/943207; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85076356891 |
| DOI: | 10.1186/s13075-019-2021-9 |
| الاتاحة: | https://hdl.handle.net/2434/943207 https://doi.org/10.1186/s13075-019-2021-9 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4868BC57 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13075-019-2021-9 |
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