Academic Journal
CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages
| العنوان: | CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages |
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| المؤلفون: | Evren, Elza, Ringqvist, Emma, Doisne, Jean-Marc, Thaller, Anna, Sleiers, Natalie, Flavell, Richard, Di Santo, James, Willinger, Tim |
| المساهمون: | Karolinska Institutet Stockholm, Immunité Innée - Innate Immunity, Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Sorbonne Paris Cité (USPC), Department of Immunobiology New Haven, CT, USA (Yale School of Medicine), Yale University New Haven, Howard Hughes Medical Institute (HHMI), This work was supported by a faculty-funded career position at Karolinska Institutet (2-1060/2018), a Karolinska Institutet Research Foundation Grant (2020-01438), a Junior Investigator and Junior Project Research Grant from the Center for Innovative Medicine financed by Region Stockholm (2-538/2014, 20190152), as well as project grants from the Swedish Research Council (2015-02413, 2019-01099), the Swedish Heart-Lung Foundation (20190198), Petrus och Augusta Hedlunds Stiftelse (M-2021-1568), and the SciLifeLab National COVID-19 Research Program, financed by the Knut and Alice Wallenberg Foundation (C19PI:G:012) to T. Willinger. E. Evren was supported by a scholarship from the Royal Swedish Academy of Sciences (BS2021-0030). A. Thaller was supported by the European Union’s Horizon 2020 research and innovation program (H2020 Marie Skłodowska-Curie Actions grant 765104). R.A. Flavell is an investigator of the Howard Hughes Medical Institute., European Project: 765104,MATURE-NK |
| المصدر: | ISSN: 0022-1007. |
| بيانات النشر: | HAL CCSD Rockefeller University Press |
| سنة النشر: | 2022 |
| المجموعة: | Institut Pasteur: HAL |
| مصطلحات موضوعية: | MESH: Animals, MESH: Biomarkers, MESH: Liver, MESH: Lung, MESH: Macrophages, Alveolar, MESH: Mice, Transgenic, MESH: Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, MESH: Stem Cells, MESH: Cell Differentiation, MESH: Cell Movement, MESH: Fetus, MESH: Gene Expression, MESH: Genes, myb, MESH: Humans, MESH: Immunohistochemistry, MESH: Immunophenotyping, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Despite their importance in lung health and disease, it remains unknown how human alveolar macrophages develop early in life. Here we define the ontogeny of human alveolar macrophages from embryonic progenitors in vivo, using a humanized mouse model expressing human cytokines (MISTRG mice). We identified alveolar macrophage progenitors in human fetal liver that expressed the GM-CSF receptor CD116 and the transcription factor MYB. Transplantation experiments in MISTRG mice established a precursor–product relationship between CD34−CD116+ fetal liver cells and human alveolar macrophages in vivo. Moreover, we discovered circulating CD116+CD64−CD115+ macrophage precursors that migrated from the liver to the lung. Similar precursors were present in human fetal lung and expressed the chemokine receptor CX3CR1. Fetal CD116+CD64− macrophage precursors had a proliferative gene signature, outcompeted adult precursors in occupying the perinatal alveolar niche, and developed into functional alveolar macrophages. The discovery of the fetal alveolar macrophage progenitor advances our understanding of human macrophage origin and ontogeny. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35019940; info:eu-repo/grantAgreement//765104/EU/MAnufacturing of TUmour-REactive Natural Killer cells/MATURE-NK; pasteur-04130567; https://hal-pasteur.archives-ouvertes.fr/pasteur-04130567; https://hal-pasteur.archives-ouvertes.fr/pasteur-04130567/document; https://hal-pasteur.archives-ouvertes.fr/pasteur-04130567/file/jem_20210987.pdf; PUBMED: 35019940; PUBMEDCENTRAL: PMC8759608 |
| DOI: | 10.1084/jem.20210987 |
| الاتاحة: | https://hal-pasteur.archives-ouvertes.fr/pasteur-04130567 https://hal-pasteur.archives-ouvertes.fr/pasteur-04130567/document https://hal-pasteur.archives-ouvertes.fr/pasteur-04130567/file/jem_20210987.pdf https://doi.org/10.1084/jem.20210987 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.4847A4CE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20210987 |
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