التفاصيل البيبلوغرافية
| العنوان: |
Structure, morphology and surface properties of α-lactose monohydrate in relation to its powder properties |
| المؤلفون: |
Nguyen, Thai T.H., Ma, Cai Y., Styliari, Ioanna D., Gajjar, Parmesh, Hammond, Robert B., Withers, Philip J., Murnane, Darragh, Roberts, Kevin J. |
| المساهمون: |
School of Life and Medical Sciences, Centre for Research into Topical Drug Delivery and Toxicology, Pharmaceutics, Airway Group, Pharmaceutical Analysis and Product Characterisation, Department of Clinical, Pharmaceutical and Biological Science |
| سنة النشر: |
2025 |
| المجموعة: |
University of Hertfordshire: UH Research Archive |
| مصطلحات موضوعية: |
Α-lactose monohydrate, Morphological characterisation, Inhalation powdered drug formulations, Synthons and intermolecular interactions, Surface energy, Surface physical chemical properties, X-ray computed tomography, Mechanical properties, Pharmaceutical Science |
| الوصف: |
© 2024 The Authors. Published by Elsevier Inc. on behalf of American Pharmacists Association. This is an open access article distributed under the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/ ; The particulate properties of α-lactose monohydrate (αLMH), an excipient and carrier for pharmaceuticals, is important for the design, formulation and performance of a wide range of drug products. Here an integrated multi-scale workflow provides a detailed molecular and inter-molecular (synthonic) analysis of its crystal morphology, surface chemistry and surface energy. Predicted morphologies are validated in 3D through X-ray diffraction (XCT) contrast tomography. Interestingly, from aqueous solution the fastest growth is found to lie along the b-axis, i.e. the longest unit cell dimension of the αLMH crystal structure reflecting the greater opportunities for solvation on the prism compared to the capping faces leading to the former's slower relative growth rates. The tomahawk morphology reflects the presence of β-lactose which asymmetrically binds to the capping surfaces creating a polar morphology. The crystal lattice energy is dominated by van der Waals interactions (between lactose molecules) with electrostatic interactions contributing the remainder. Predicted total surface energies are in good agreement with those measured at high surface coverage by inverse gas chromatography, albeit their dispersive contributions are found to be higher than those measured. The calculated surface energies of crystal habit surfaces are not found to be significantly different between different crystal surfaces, consistent with αLMH's known homogeneous binding to drug molecules when formulated. Surface energies for different morphologies reveals that crystals with the elongated crystal morphologies have lower surface energies compared to those with a triangular or tomahawk morphologies, correlating well with literature data that the surface energies of the lactose carriers are inversely ... |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
English |
| Relation: |
Journal of Pharmaceutical Sciences; RIS: urn:8159A46EEAA645569A6C51C0840D9CC1; http://hdl.handle.net/2299/28611; http://www.scopus.com/inward/record.url?scp=85210995596&partnerID=8YFLogxK |
| الاتاحة: |
http://hdl.handle.net/2299/28611
http://www.scopus.com/inward/record.url?scp=85210995596&partnerID=8YFLogxK |
| رقم الانضمام: |
edsbas.484340C |
| قاعدة البيانات: |
BASE |