Conference
Anticancer activity of 2,5-substituted thiazolidinone derivatives
| العنوان: | Anticancer activity of 2,5-substituted thiazolidinone derivatives |
|---|---|
| المؤلفون: | Savukynaitė, Lina, Petrikaitė, Vilma |
| المصدر: | The 6th International Pharmaceutical Conference "Science and Practice 2015" : book of abstracts : November 5-6, 2015, Kaunas, Lithuania / Faculty of Pharmacy of Lithuanian university of Health Sciences. LSMU FF Alumni association. Lithuanian Pharmaceutical association. Lithuanian Pharmacists' Society, Kaunas : Lithuanian university of Health Sciences, 2015, p. 64-65 ; ISBN 9789955154105 |
| سنة النشر: | 2015 |
| المجموعة: | LSRC VL (Lithuanian Social Research Centre Virtual Library) / LSTC VB (Lietuvos socialinių tyrimų centras virtualią biblioteką) |
| مصطلحات موضوعية: | Thiazolidines, chemistry, pharmacology, Antineoplastic agents, chemical synthesis, info:eu-repo/classification/udc/615.277.3 |
| الوصف: | Thiazolidinones are five-membered ring heterocyclic compounds having sulphur atom at position 1 and nitrogen atoma at position 3, meanwhile the carbonyl group can occupy positions 2, 4 or 5. Adding substituents to the structure affects the compounds properties and their biological activity. Thiazolidinone derivatives have a broad spectrum of biological and pharmacological effects, including anticancer activity. 4-thiazolidinone derivatives substituted with pyrazoline and benzothiazole at 2 position show high levels of anticancer activity. The aim of our research was to evaluate anticancer activity, pharmacokinetic properties and toxicity of novel thiazolidinone derivatives substituted at positions 2 and 5. Structure of these compounds was confirmed by elemental analysis, ¹H NMR, IR and MS/MS. Purity was determined by HPLC/MS and was in the range of 93-99%. The cell growth inhibitory effects of compounds were tested using MTT assay on human lung carcinoma (A549), glioblastoma (U87) and melanoma (IGR39) cells. Apoptotic and necrotic effects were tested using Hoechst 33342 and Propidium iodide double staining. The toxicity and pharmacokinetic properties of the compounds were evaluated in silico using ACD/I-Lab software. [.]. |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| ردمك: | 978-9955-15-410-5 9955-15-410-1 |
| Relation: | http://lsmu.lvb.lt/LSMU:ELABAPDB15378283&prefLang=en_US |
| الاتاحة: | http://lsmu.lvb.lt/LSMU:ELABAPDB15378283&prefLang=en_US |
| رقم الانضمام: | edsbas.47CFDC16 |
| قاعدة البيانات: | BASE |
| ردمك: | 9789955154105 9955154101 |
|---|