Academic Journal
Increase in Neuroexcitability of Unmyelinated C‐type Vagal Ganglion Neurons During Initial Postnatal Development of Visceral Afferent Reflex Functions
| العنوان: | Increase in Neuroexcitability of Unmyelinated C‐type Vagal Ganglion Neurons During Initial Postnatal Development of Visceral Afferent Reflex Functions |
|---|---|
| المؤلفون: | Qian, Zhao, Liu, Dong‐Jie, Liu, Yang, Han, Li‐Min, Yuan, Mei, Li, Jun‐Nan, Xu, Bing, Lu, Xiao‐Long, Cao, Pan‐Xiang, Wang, Hao‐Yan, Pan, Xiao‐Dong, Wang, Li‐Juan, Qiao, Guo‐Fen, Li, Bai‐Yan |
| المصدر: | CNS Neuroscience & Therapeutics ; volume 19, issue 12, page 954-962 ; ISSN 1755-5930 1755-5949 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2013 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary Background Baroreflex gain increase up closely to adult level during initial postnatal weeks, and any interruption within this period will increase the risk of cardiovascular problems in later of life span. We hypothesize that this short period after birth might be critical for postnatal development of vagal ganglion neurons ( VGN s). Methods To evaluate neuroexcitability evidenced by discharge profiles and coordinate changes, ion currents were collected from identified A‐ and C‐type VGN s at different developmental stages using whole‐cell patch clamping. Results C‐type VGN s underwent significant age‐dependent transition from single action potential ( AP ) to repetitive discharge. The coordinate changes between TTX ‐S and TTX ‐R Na + currents were also confirmed and well simulated by computer modeling. Although 4‐ AP or iberiotoxin age dependently increased firing frequency, AP duration was prolonged in an opposite fashion, which paralleled well with postnatal changes in 4‐ AP ‐ and iberiotoxin‐sensitive K + current activity, whereas less developmental changes were verified in A‐types. Conclusion These data demonstrate for the first time that the neuroexcitability of C‐type VGN s increases significantly compared with A‐types within initial postnatal weeks evidenced by AP discharge profiles and coordinate ion channel changes, which explain, at least in part, that initial postnatal weeks may be crucial for ontogenesis in visceral afferent reflex function. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/cns.12195 |
| الاتاحة: | http://dx.doi.org/10.1111/cns.12195 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcns.12195 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cns.12195 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.47C29854 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cns.12195 |
|---|