Academic Journal
Cardiometabolic Disease Burden and Steroid Excretion in Benign Adrenal Tumors : A Cross-Sectional Multicenter Study
| العنوان: | Cardiometabolic Disease Burden and Steroid Excretion in Benign Adrenal Tumors : A Cross-Sectional Multicenter Study |
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| المؤلفون: | Prete, Alessandro, Subramanian, Anuradhaa, Bancos, Irina, Chortis, Vasileios, Tsagarakis, Stylianos, Lang, Katharina, Macech, Magdalena, Delivanis, Danae A, Pupovac, Ivana D, Reimondo, Giuseppe, Marina, Ljiljana V, Deutschbein, Timo, Balomenaki, Maria, O'Reilly, Michael W, Gilligan, Lorna C, Jenkinson, Carl, Bednarczuk, Tomasz, Zhang, Catherine D, Dusek, Tina, Diamantopoulos, Aristidis, Asia, Miriam, Kondracka, Agnieszka, Li, Dingfeng, Masjkur, Jimmy R, Quinkler, Marcus, Ueland, Grethe Å, Dennedy, M Conall, Beuschlein, Felix, Tabarin, Antoine, Fassnacht, Martin, Ivović, Miomira, Terzolo, Massimo, Kastelan, Darko, Young, William F, Manolopoulos, Konstantinos N, Ambroziak, Urszula, Vassiliadi, Dimitra A, Taylor, Angela E, Sitch, Alice J, Nirantharakumar, Krishnarajah, Arlt, Wiebke |
| المساهمون: | Prete, Alessandro, Subramanian, Anuradhaa, Bancos, Irina, Chortis, Vasileio, Tsagarakis, Styliano, Lang, Katharina, Macech, Magdalena, Delivanis, Danae A, Pupovac, Ivana D, Reimondo, Giuseppe, Marina, Ljiljana V, Deutschbein, Timo, Balomenaki, Maria, O'Reilly, Michael W, Gilligan, Lorna C, Jenkinson, Carl, Bednarczuk, Tomasz, Zhang, Catherine D, Dusek, Tina, Diamantopoulos, Aristidi, Asia, Miriam, Kondracka, Agnieszka, Li, Dingfeng, Masjkur, Jimmy R, Quinkler, Marcu, Ueland, Grethe Å, Dennedy, M Conall, Beuschlein, Felix, Tabarin, Antoine, Fassnacht, Martin, Ivović, Miomira, Terzolo, Massimo, Kastelan, Darko, Young, William F, Manolopoulos, Konstantinos N, Ambroziak, Urszula, Vassiliadi, Dimitra A, Taylor, Angela E, Sitch, Alice J, Nirantharakumar, Krishnarajah, Arlt, Wiebke |
| سنة النشر: | 2022 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| الوصف: | Background: Benign adrenal tumors are commonly discovered on cross-sectional imaging. Mild autonomous cortisol secretion (MACS) is regularly diagnosed, but its effect on cardiometabolic disease in affected persons is ill defined. Objective: To determine cardiometabolic disease burden and steroid excretion in persons with benign adrenal tumors with and without MACS. Design: Cross-sectional study. Setting: 14 endocrine secondary and tertiary care centers (recruitment from 2011 to 2016). Participants: 1305 prospectively recruited persons with benign adrenal tumors. Measurements: Cortisol excess was defined by clinical assessment and the 1-mg overnight dexamethasone-suppression test (serum cortisol: <50 nmol/L, nonfunctioning adrenal tumor [NFAT]; 50 to 138 nmol/L, possible MACS [MACS-1]; >138 nmol/L and absence of typical clinical Cushing syndrome [CS] features, definitive MACS [MACS-2]). Net steroid production was assessed by multisteroid profiling of 24-hour urine by tandem mass spectrometry. Results: Of the 1305 participants, 49.7% had NFAT (n = 649; 64.1% women), 34.6% had MACS-1 (n = 451; 67.2% women), 10.7% had MACS-2 (n = 140; 73.6% women), and 5.0% had CS (n = 65; 86.2% women). Prevalence and severity of hypertension were higher in MACS-2 and CS than NFAT (adjusted prevalence ratios [aPRs] for hypertension: MACS-2, 1.15 [95% CI, 1.04 to 1.27], and CS, 1.37 [CI, 1.16 to 1.62]; aPRs for use of ≥3 antihypertensives: MACS-2, 1.31 [CI, 1.02 to 1.68], and CS, 2.22 [CI, 1.62 to 3.05]). Type 2 diabetes was more prevalent in CS than NFAT (aPR, 1.62 [CI, 1.08 to 2.42]) and more likely to require insulin therapy for MACS-2 (aPR, 1.89 [CI, 1.01 to 3.52]) and CS (aPR, 3.06 [CI, 1.60 to 5.85]). Urinary multisteroid profiling revealed an increase in glucocorticoid excretion from NFAT over MACS-1 and MACS-2 to CS, whereas androgen excretion decreased. Limitations: Cross-sectional design; possible selection bias. Conclusion: A cardiometabolic risk condition, MACS predominantly affects women and warrants regular ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34978855; volume:3; issue:175; firstpage:325; lastpage:334; numberofpages:10; journal:ANNALS OF INTERNAL MEDICINE; http://hdl.handle.net/2318/1833101 |
| DOI: | 10.7326/M21-1737 |
| DOI: | 10.7326/M21-1737?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub |
| الاتاحة: | http://hdl.handle.net/2318/1833101 https://doi.org/10.7326/M21-1737 https://www.acpjournals.org/doi/10.7326/M21-1737?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub 0pubmed |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.47257160 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7326/M21-1737 |
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