Conference
Biopolymer-based wound dressings : from film casting towards electrospinning
| العنوان: | Biopolymer-based wound dressings : from film casting towards electrospinning |
|---|---|
| المؤلفون: | Stubbe, Birgit, Compernolle, Niels, Van Vlierberghe, Sandra, Hoeksema, Hendrik, Vanhaecke, Frank, Monstrey, Stan, Dubruel, Peter |
| المصدر: | BPG 2014 annual meeting, Book of abstracts |
| سنة النشر: | 2014 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences |
| الوصف: | The survival rates of burn wound patients have increased significantly during the past decades thanks to the development of state-of-the-art diagnostic tools and treatments. However, patients still suffer from prolonged physical and psychological pains. In addition, they are also facing a heavy financial burden. A universal wound dressing does not exist to date since wound characteristics can greatly differ and vary over time. There exist however a number of criteria that wound dressings should ideally fulfill such as maintaining a moist environment, enable the exchange of gases, be impermeable for micro-organisms, be non-adherent, be biocompatible, provide mechanical support,etc. Commonly used (burn) dressings including Kaltostat®, Flaminal®, etc. consist of alginates.[1] These linear polysaccharides extracted from brown algae are biocompatible and known for their ability to absorb and retain very large amounts of exudate, hereby creating an optimal moist wound environment.[2-3] Another interesting biopolymer is gelatin, which is a water-soluble protein and a derivative of collagen. The latter is a very important structural protein in the human body, including the skin.[4] Interestingly, unlike alginate, gelatin shows cell-interactive properties which can be an advantage when it comes to wound repair.[5] In the present work, gelatin and alginate have been modified with methacrylamide and methacrylate functionalities, respectively and chemically crosslinked through UV irradiation. The hydrogel networks developed starting from the functionalized biopolymers have been subsequently characterized using IR-mapping, rheology and swelling experiments. Interestingly, in addition to conventional polymer networks, double networks or interpenetrating polymer networks (IPN's) have been processed by incubating a UV-crosslinked gelatin-methacrylamide hydrogel film in a (modified) alginate solution, followed by a second crosslinking procedure using either UV irradiation or Ca2+ ions. In addition to conventional film casting, ... |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| Relation: | https://biblio.ugent.be/publication/4413187 |
| الاتاحة: | https://biblio.ugent.be/publication/4413187 http://hdl.handle.net/1854/LU-4413187 |
| رقم الانضمام: | edsbas.4712C5E7 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |