Academic Journal
Keratin Expression in Podocytopathies, ANCA-Associated Vasculitis and IgA Nephropathy
| العنوان: | Keratin Expression in Podocytopathies, ANCA-Associated Vasculitis and IgA Nephropathy |
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| المؤلفون: | Paraskevi Pavlakou, Harikleia Gakiopoulou, Sonja Djudjaj, Kostas Palamaris, Maria Stella Trivyza, Kostas Stylianou, Dimitrios S. Goumenos, Evangelos Papachristou, Marios Papasotiriou |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 3, p 1805 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | keratins, glomerulonephritis, biomarker, end-stage kidney disease, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Keratins are the main components of the cell cytoskeleton of epithelial cells. Epithelial cells under stressful stimuli react by modifying their keratin expression pattern. Glomerular diseases are pathological conditions that may lead to loss of kidney function if not timely diagnosed and treated properly. This study aims to examine glomerular and tubular keratin expression in podocytopathies, ANCA-associated vasculitis, and IgA nephropathy and how this expression correlates to clinical outcomes. We included 45 patients with podocytopathies (minimal change disease and focal segmental glomerulosclerosis), ANCA-associated vasculitis, and IgA nephropathy, with or without crescentic lesions, and healthy controls. All tissues were assessed by photon microscopy and immunohistochemistry. Biopsy sections were examined for keratins 7, 8, 18, and 19 expression in the glomerular and tubulointerstitial areas separately. Moreover, we examined how keratin expression was correlated with long-term kidney function outcomes. All four studied keratins had significantly increased glomerular expression in patients with ANCA vasculitis compared to controls and MCD patients. Tubular expression of keratins 7, 8, and 19 was related to kidney outcome in all groups. Patients with crescents had higher expression of all keratins in both glomeruli and tubulointerstitium. The presence of tubular atrophy, interstitial fibrosis, mesangial hyperplasia, and interstitial inflammation did not affect keratin expression. Keratins, an abundant component of renal epithelial cells, have the potential to be featured as a biomarker for kidney function prognosis in patients with glomerular diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/3/1805; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/5ca78f92fd44463eadfbd7220a66a466 |
| DOI: | 10.3390/ijms25031805 |
| الاتاحة: | https://doi.org/10.3390/ijms25031805 https://doaj.org/article/5ca78f92fd44463eadfbd7220a66a466 |
| رقم الانضمام: | edsbas.46FB2AF1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25031805 |