Academic Journal
Maintaining the Balance: Regulation of NK Cell Activity
| العنوان: | Maintaining the Balance: Regulation of NK Cell Activity |
|---|---|
| المؤلفون: | Imširović, Vanna, Wensveen, Felix M., Polić, Bojan, Jelenčić, Vedrana |
| المصدر: | https://www.mdpi.com/2073-4409/13/17/1464 ; Cells ; Volume 13 ; Issue 17 ; ISSN 2073-4409 (Online. |
| سنة النشر: | 2024 |
| المجموعة: | Repository of the University of Rijeka |
| مصطلحات موضوعية: | NK cells, activation, inhibitory receptors, activating receptors, BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti, BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences |
| الوصف: | Natural Killer (NK) cells, integral components of the innate immune system, play a crucial role in the protection against intracellular threats. Their cytotoxic power requires that activation is tightly controlled, and in this, they take a unique position within the immune system. Rather than depending on the engagement of a single activating receptor, their activation involves a delicate balance between inhibitory and activating signals mediated through an array of surface molecules. Only when this cumulative balance surpasses a specific threshold do NK cells initiate their activity. Remarkably, the activation threshold of NK cells remains robust even when cells express vastly different repertoires of inhibitory and activating receptors. These threshold values seem to be influenced by NK cell interactions with their environment during development and after release from the bone marrow. Understanding how NK cells integrate this intricate pattern of stimuli is an ongoing area of research, particularly relevant for cellular therapies seeking to harness the anti-cancer potential of these cells by modifying surface receptor expression. In this review, we will explore some of the current dogmas regarding NK cell activation and discuss recent literature addressing advances in our understanding of this field. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/grantAgreement/Hrvatska zaklada za znanost/Installation Research Projects/UIP-2019-04-9390/HR/Elucidation of molecular and functional properties of master regulators of NK cell activation/NK-MASTERS; Sveučilište u Rijeci. Medicinski fakultet. Katedra za histologiju i embriologiju.; University of Rijeka. Faculty of Medicine. Department of Histology and Embryology.; https://www.unirepository.svkri.uniri.hr/islandora/object/medri:9002; https://urn.nsk.hr/urn:nbn:hr:184:957161; https://www.unirepository.svkri.uniri.hr/islandora/object/medri:9002/datastream/FILE0 |
| الاتاحة: | https://www.unirepository.svkri.uniri.hr/islandora/object/medri:9002 https://urn.nsk.hr/urn:nbn:hr:184:957161 https://www.unirepository.svkri.uniri.hr/islandora/object/medri:9002/datastream/FILE0 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.46E5F403 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |