Academic Journal
Is there an immunological cross-reactivity of antibodies to the myelin oligodendrocyte glycoprotein and coronaviruses?
| العنوان: | Is there an immunological cross-reactivity of antibodies to the myelin oligodendrocyte glycoprotein and coronaviruses? |
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| المؤلفون: | Schanda, Kathrin, Mariotto, Sara, Rudzki, Dagmar, Bauer, Angelika, Dinoto, Alessandro, Rossi, Patrizia, Ferrari, Sergio, Jarius, Sven, Wildemann, Brigitte, Boso, Federica, Giometto, Bruno, Engels, Daniel, Kümpfel, Tania, Wendel, Eva-Maria, Rostasy, Kevin, Reindl, Markus |
| المساهمون: | Schanda, Kathrin, Mariotto, Sara, Rudzki, Dagmar, Bauer, Angelika, Dinoto, Alessandro, Rossi, Patrizia, Ferrari, Sergio, Jarius, Sven, Wildemann, Brigitte, Boso, Federica, Giometto, Bruno, Engels, Daniel, Kümpfel, Tania, Wendel, Eva-Maria, Rostasy, Kevin, Reindl, Markus |
| سنة النشر: | 2024 |
| المجموعة: | Università degli Studi di Trento: CINECA IRIS |
| مصطلحات موضوعية: | MOG, SARS-CoV-2, antibody, cross-reactivity, nucleocapsid protein |
| الوصف: | Recent reports indicated that myelin oligodendrocyte glycoprotein antibody-associated disease might be a rare complication after severe acute respiratory syndrome coronavirus 2 infection or vaccination. It is unclear whether this is an unspecific sequel of infection or vaccination or caused by possible immunological cross-reactivity of severe acute respiratory syndrome coronavirus 2 proteins and myelin oligodendrocyte glycoprotein. The aim of this study was therefore to elucidate whether there is an immunological cross-reactivity between severe acute respiratory syndrome coronavirus 2 spike or nucleocapsid proteins and myelin oligodendrocyte glycoprotein and to explore the relation of antibody responses against myelin oligodendrocyte glycoprotein and severe acute respiratory syndrome coronavirus 2 and other coronaviruses. We analysed serum samples from patients with severe acute respiratory syndrome coronavirus 2 infection and neurological symptoms with (myelin oligodendrocyte glycoprotein antibody-associated disease, n = 12) or without myelin oligodendrocyte glycoprotein-antibodies (n = 10); severe acute respiratory syndrome coronavirus 2 infection without neurological symptoms (n = 32); vaccinated patients with no history of severe acute respiratory syndrome coronavirus 2 infection and neurological symptoms with (myelin oligodendrocyte glycoprotein antibody-associated disease, n = 10) or without myelin oligodendrocyte glycoprotein-antibodies (n = 9); and severe acute respiratory syndrome coronavirus 2 negative/naïve unvaccinated patients with neurological symptoms with (myelin oligodendrocyte glycoprotein antibody-associated disease, n = 47) or without myelin oligodendrocyte glycoprotein-antibodies (n = 20). All samples were analysed for serum antibody responses to myelin oligodendrocyte glycoprotein, severe acute respiratory syndrome coronavirus 2, and other common coronaviruses (CoV-229E, CoV-HKU1, CoV-NL63 and CoV-OC43). Based on sample amount and antibody titres, 21 samples were selected for analysis of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38576796; info:eu-repo/semantics/altIdentifier/wos/WOS:001216872600012; volume:2024, 6; issue:2; firstpage:1; lastpage:17; numberofpages:17; journal:BRAIN COMMUNICATIONS; https://hdl.handle.net/11572/427030; https://academic.oup.com/braincomms/article/6/2/fcae106/7634794?login=false |
| DOI: | 10.1093/braincomms/fcae106 |
| الاتاحة: | https://hdl.handle.net/11572/427030 https://doi.org/10.1093/braincomms/fcae106 https://academic.oup.com/braincomms/article/6/2/fcae106/7634794?login=false |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.46844E13 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/braincomms/fcae106 |
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