Academic Journal
THE DYNAMICS OF CYTOLYSIS MARKERS UNDER CONDITIONS OF ACUTE BLOOD LOSS COMPLICATED BY LIMB ISCHEMIA-REPERFUSION AND THEIR CORRECTION BY CARBACETAM ; ДИНАМИКА ПОКАЗАТЕЛЕЙ ЦИТОЛИЗА В УСЛОВИЯХ ОСТРОЙ КРОВОПОТЕРИ, ОСЛОЖНЕННОЙ ИШЕМИЕЙ-РЕПЕРФУЗИЕЙ КОНЕЧНОСТИ, И ИХ КОРРЕКЦИЯ КАРБАЦЕТАМОМ ; ДИНАМІКА ПОКАЗНИКІВ ЦИТОЛІЗУ ЗА УМОВ ГОСТРОЇ КРОВОВТРАТИ, УСКЛАДНЕНОЇ ІШЕМІЄЮ-РЕПЕРФУЗІЄЮ КІНЦІВКИ, ТА ЇХ КОРЕКЦІЯ КАРБАЦЕТАМОМ
| العنوان: | THE DYNAMICS OF CYTOLYSIS MARKERS UNDER CONDITIONS OF ACUTE BLOOD LOSS COMPLICATED BY LIMB ISCHEMIA-REPERFUSION AND THEIR CORRECTION BY CARBACETAM ; ДИНАМИКА ПОКАЗАТЕЛЕЙ ЦИТОЛИЗА В УСЛОВИЯХ ОСТРОЙ КРОВОПОТЕРИ, ОСЛОЖНЕННОЙ ИШЕМИЕЙ-РЕПЕРФУЗИЕЙ КОНЕЧНОСТИ, И ИХ КОРРЕКЦИЯ КАРБАЦЕТАМОМ ; ДИНАМІКА ПОКАЗНИКІВ ЦИТОЛІЗУ ЗА УМОВ ГОСТРОЇ КРОВОВТРАТИ, УСКЛАДНЕНОЇ ІШЕМІЄЮ-РЕПЕРФУЗІЄЮ КІНЦІВКИ, ТА ЇХ КОРЕКЦІЯ КАРБАЦЕТАМОМ |
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| المؤلفون: | Horban, I. I., Hudyma, A. A., Maksymiv, R. V. |
| المصدر: | Medical and Clinical Chemistry; No. 2 (2020); 23-30 ; Медицинская и клиническая химия; № 2 (2020); 23-30 ; Медична та клінічна хімія; № 2 (2020); 23-30 ; 2414-9934 ; 2410-681X ; 10.11603/mcch.2410-681X.2020.v.i2 |
| بيانات النشر: | Ternopil National Medical University |
| سنة النشر: | 2020 |
| المجموعة: | Scientific Journals of Ternopil State Medical University / Наукові журнали Тернопільського державного медичного університету імені І.Я.Горбачевського |
| مصطلحات موضوعية: | acute blood loss, limb ischemia-reperfusion, cytolytic syndrome, carbacetam, острая кровопотеря, ишемия-реперфузия конечности, цитолитический синдром, карбацетам, гостра крововтрата, ішемія-реперфузія кінцівки, цитолітичний синдром |
| الوصف: | Introduction. The main means of saving the wounded on the battlefield in conditions of massive blood loss from the limbs is the use of a hemostatic tourniquet. It is known that complete bleeding of the extremity for 2 hours during the reperfusion period is accompanied by activation of lipid peroxidation processes, which increases with acute blood loss, is accompanied by degradation of cell membranes and causes the development of cytolysis syndrome. The aim of the study – to determine the dynamics of cytolysis markers in the presence of acute blood loss complicated by limb ischemia-reperfusion and the efficacy of their correction by carbacetam. Research Methods. In experiments on nonlinear white male rats under thiopental sodium anesthesia, two-hour limb ischemia was simulated followed by reperfusion, acute blood loss (20 % of the circulating blood volume), and these injuries were combined. In a separate study group in conditions of acute blood loss and limb ischemia-reperfusion, rats were injected intraperitoneally with a dose of 5 mg/kg of animal weight for rats with a corrective purpose. In the control group, rats were anesthetized. After 1 and 2 hours, and also after 1, 7 and 14 days under thiopental sodium anesthesia, experimental animals were removed from the experiment by the method of total bloodletting from the heart. The content of cytolysis markers in the blood serum was determined: the activity of alanine and aspartate aminotransferases (AlAT, AsAT). Results and Discussion. Modeling of limb ischemia-reperfusion was accompanied by a pronounced cytolytic syndrome, which, in comparison with the control, was manifested by a significant increase in serum activity of AlAT and AsAT after 3 hours and 1 day of observation. Starting from 7 days, the indicators returned to normal. Modeling of acute blood loss deepened the activity of cytolysis processes. The studied parameters were greater than the control level at all observation periods with a maximum after 1 day of the experiment and significantly exceeded ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Ukrainian |
| Relation: | https://ojs.tdmu.edu.ua/index.php/MCC/article/view/11354/10780; https://ojs.tdmu.edu.ua/index.php/MCC/article/view/11354 |
| DOI: | 10.11603/mcch.2410-681X.2020.v.i2.11354 |
| الاتاحة: | https://ojs.tdmu.edu.ua/index.php/MCC/article/view/11354 https://doi.org/10.11603/mcch.2410-681X.2020.v.i2.11354 |
| رقم الانضمام: | edsbas.46661B77 |
| قاعدة البيانات: | BASE |
| DOI: | 10.11603/mcch.2410-681X.2020.v.i2.11354 |
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