Academic Journal
Nucleolar localization of the ErbB3 receptor as a new target in glioblastoma
| العنوان: | Nucleolar localization of the ErbB3 receptor as a new target in glioblastoma |
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| المؤلفون: | Marzia Tagliaferro, Paolo Rosa, Gian Carlo Bellenchi, Daniela Bastianelli, Rosa Trotta, Claudia Tito, Francesco Fazi, Antonella Calogero, Donatella Ponti |
| المساهمون: | Tagliaferro, Marzia, Rosa, Paolo, Carlo Bellenchi, Gian, Bastianelli, Daniela, Trotta, Rosa, Tito, Claudia, Fazi, Francesco, Calogero, Antonella, Ponti, Donatella |
| بيانات النشر: | BMC London |
| سنة النشر: | 2022 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | ErbB3, neuregulin, nucleolu, UBF, nucleolin, glioblastoma, actinomycin D |
| الوصف: | Background: The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis and a critical regulator of cell homeostasis. Rapid growth and division of cells in tumors are correlated with intensive nucleolar metabolism as a response to oncogenic factors overexpression. Several members of the Epidermal Growth Factor Receptor (EGFR) family, have been identifed in the nucleus and nucleolus of many cancer cells, but their function in these compartments remains unexplored. Results: We focused our research on the nucleolar function that a specifc member of EGFR family, the ErbB3 receptor, plays in glioblastoma, a tumor without efective therapies. Here, Neuregulin 1 mediated proliferative stimuli, promotes ErbB3 relocalization from the nucleolus to the cytoplasm and increases pre-rRNA synthesis. Instead ErbB3 silencing or nucleolar stress reduce cell proliferation and afect cell cycle progression. Conclusions: These data point to the existence of an ErbB3-mediated non canonical pathway that glioblastoma cells use to control ribosomes synthesis and cell proliferation. These results highlight the potential role for the nucleolar ErbB3 receptor, as a new target in glioblastoma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35255831; info:eu-repo/semantics/altIdentifier/wos/WOS:000765778800001; volume:23; issue:1; firstpage:1; lastpage:14; numberofpages:14; journal:BMC MOLECULAR AND CELL BIOLOGY; http://hdl.handle.net/11573/1616393; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85125977154 |
| DOI: | 10.1186/s12860-022-00411-y |
| الاتاحة: | http://hdl.handle.net/11573/1616393 https://doi.org/10.1186/s12860-022-00411-y |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.465302FB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12860-022-00411-y |
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