Academic Journal
The impact of obesity in the cardiac lipidome and its consequences in the cardiac damage observed in obese rats ; El impacto de la obesidad sobre el lipidoma cardiaco y sus consecuencias en el daño cardiaco en ratas obesas
| العنوان: | The impact of obesity in the cardiac lipidome and its consequences in the cardiac damage observed in obese rats ; El impacto de la obesidad sobre el lipidoma cardiaco y sus consecuencias en el daño cardiaco en ratas obesas |
|---|---|
| المؤلفون: | Marín-Royo, Gema, Martínez-Martínez, Ernesto, Gutiérrez, Beatriz, Jurado-López, Raquel, Gallardo, Isabel, Montero, Olimpio, Bartolomé, María Visitacion, San Román, José Alberto, Salaices, Mercedes, Nieto, María Luisa, Cachofeiro, Victoria |
| المساهمون: | Sociedad Española de Arteriosclerosis, Ministerio de Economía y Competitividad (España), European Commission, Junta de Castilla y León |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2018 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Lipid profiling, Obesity, Cardiac remodeling, Fibrosis, Lipidómica, Obesidad, Remodelado cardiaco |
| الوصف: | [EN]: [Aims] To explore the impact of obesity on the cardiac lipid profile in rats with diet-induced obesity, as well as to evaluate whether or not the specific changes in lipid species are associated with cardiac fibrosis. [Methods] Male Wistar rats were fed either a high-fat diet (HFD, 35% fat) or standard diet (3.5% fat) for 6 weeks. Cardiac lipids were analyzed using by liquid chromatography-tandem mass spectrometry. [Results] HFD rats showed cardiac fibrosis and enhanced levels of cardiac superoxide anion (O2), HOMA index, adiposity, and plasma leptin, as well as a reduction in those of cardiac glucose transporter (GLUT 4), compared with control animals. Cardiac lipid profile analysis showed a significant increase in triglycerides, especially those enriched with palmitic, stearic, and arachidonic acid. An increase in levels of diacylglycerol (DAG) was also observed. No changes in cardiac levels of diacyl phosphatidylcholine, or even a reduction in total levels of diacyl phosphatidylethanolamine, diacyl phosphatidylinositol, and sphingomyelins (SM) was observed in HFD, as compared with control animals. After adjustment for other variables (oxidative stress, HOMA, cardiac hypertrophy), total levels of DAG were independent predictors of cardiac fibrosis while the levels of total SM were independent predictors of the cardiac levels of GLUT 4. [Conclusions] These data suggest that obesity has a significant impact on cardiac lipid composition, although it does not modulate the different species in a similar manner. Nonetheless, these changes are likely to participate in the cardiac damage in the context of obesity, since total DAG levels can facilitate the development of cardiac fibrosis, and SM levels predict GLUT4 levels. ; [ES]: [Objetivos] Explorar el impacto de la obesidad sobre el perfil lipídico cardiaco en ratas con obesidad inducida por dieta. Se evaluó, además, si estos cambios se asocian con fibrosis cardiaca. [Métodos] Ratas macho Wistar fueron alimentadas con una dieta con alto contenido en grasa ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0214-9168 1578-1879 |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-81063-R; Postprint; https://doi.org/10.1016/j.arteri.2017.07.004; Sí; Clínica e Investigación en Arteriosclerosis 30(1): 10-20 (2018); http://hdl.handle.net/10261/196909; http://dx.doi.org/10.13039/501100003329; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/501100014180 |
| DOI: | 10.1016/j.arteri.2017.07.004 |
| DOI: | 10.13039/501100003329 |
| DOI: | 10.13039/501100000780 |
| DOI: | 10.13039/501100014180 |
| الاتاحة: | http://hdl.handle.net/10261/196909 https://doi.org/10.1016/j.arteri.2017.07.004 https://doi.org/10.13039/501100003329 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100014180 |
| Rights: | open |
| رقم الانضمام: | edsbas.4652D1FD |
| قاعدة البيانات: | BASE |
| تدمد: | 02149168 15781879 |
|---|---|
| DOI: | 10.1016/j.arteri.2017.07.004 |