Academic Journal
Regional differences in the in vitro penetration of methylsalicylate through equine skin
| العنوان: | Regional differences in the in vitro penetration of methylsalicylate through equine skin |
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| المؤلفون: | Mills, P. C., Cross, S. E. |
| المساهمون: | A. J. Higgins |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2007 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Veterinary Sciences, Horse, Transdermal methylsalicylate, Salicylate, In vitro, Deep Tissue Penetration, Percutaneous-absorption, Transfollicular Routes, Topical Penetration, Methyl Salicylate, Synovial-fluid, Sites, Drug, Hydrocortisone, Patches, 300501 Veterinary Medicine, 300512 Pharmacology, C1, 730109 Surgical methods and procedures, 780105 Biological sciences |
| الوصف: | Commercial formulations of non-steroidal anti-inflammatory drugs (NSAIDs) are developed for human use but the extent to which they will pass through equine skin is unknown. Skin was harvested from five Thoroughbred geldings from the thorax, groin and leg (dorsal metacarpal) regions and frozen (-20 degrees C) until required. Two grams of methylsalicylate (Mesa) gel was applied to defrosted full-thickness samples in diffusion cells and the penetration of Mesa and its active metabolite, salicylate (Sa), through skin samples were measured over 24 h. Significantly higher (P |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1090-0233 1532-2971 |
| Relation: | orcid:0000-0001-9030-9666 |
| الاتاحة: | https://espace.library.uq.edu.au/view/UQ:131920 |
| رقم الانضمام: | edsbas.4644B81D |
| قاعدة البيانات: | BASE |
| تدمد: | 10900233 15322971 |
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