التفاصيل البيبلوغرافية
| العنوان: |
Gender-related differences in urinary 6-sulfatoxymelatonin levels in obese pubertal individuals |
| المؤلفون: |
Fideleff, Hugo L., Boquete, Hugo, Fideleff, Gabriel, Albornoz, Liliana, Perez Lloret, Santiago, Suarez, Marta, Esquifino, Ana I., Honfi,Margarita, Cardinali, Daniel Pedro |
| بيانات النشر: |
Wiley Blackwell Publishing, Inc |
| المجموعة: |
CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: |
https://purl.org/becyt/ford/3.2, https://purl.org/becyt/ford/3 |
| الوصف: |
The objective of this study was to measure the urinary excretion of the main melatonin metabolite 6-sulfatoxymelatonin in obese and normal weight (wt) boys and girls. The study included 94 subjects, aged 4-15.7 yr (50 obese and 44 normal wt; 48 boys) classified as: mid-childhood (4-7.99 yr), late-childhood (8-12 yr) and pubertal (10.1-15.7 yr, Tanner II-IV). Normal wt subjects were children with a body mass index (BMI) between the 25th and 75th percentiles, and the group of obese subjects included children whose BMI was above the 97th percentile. A 24-hr urine sample was collected during two intervals: (i) 18:00-08:00 hr, and (ii) 08:00-18:00 hr. Analysis of urinary 6-sulfatoxymelatonin levels was performed by radioimmunoassay. Excretion of 6-sulfatoxymelatonin was expressed as: (i) total amount excreted (microg); (ii) mug excreted per time interval, nocturnal or diurnal; and (iii) the difference between nocturnal and diurnal samples (microg, estimated amplitude). A factorial analysis of variance indicated that nocturnal 6-sulfatoxymelatonin excretion and amplitude were significantly higher in the obese individuals. A significant interaction 'BMI x age' was detected, i.e. the effect of BMI was significant in the pubertal group only. Total, nocturnal and diurnal 6-sulfatoxymelatonin excretion was significantly higher in girls. The increase in 6-sulfatoxymelatonin excretion found in obesity occurred only in boys and at the pubertal age. To what extent this increase in melatonin production contributes to a delayed puberty in some pubertal obese males remains to be established. ; Fil: Fideleff, Hugo L. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina ; Fil: Boquete, Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina ; Fil: Fideleff, Gabriel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina ; Fil: Albornoz, Liliana. Universidad de Buenos Aires. Facultad de Medicina; ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0742-3098 |
| Relation: |
http://hdl.handle.net/11336/110101; Fideleff, Hugo L.; Boquete, Hugo; Fideleff, Gabriel; Albornoz, Liliana; Perez Lloret, Santiago; et al.; Gender-related differences in urinary 6-sulfatoxymelatonin levels in obese pubertal individuals; Wiley Blackwell Publishing, Inc; Journal of Pineal Research; 40; 3; 4-2006; 214-218; CONICET Digital; CONICET |
| الاتاحة: |
http://hdl.handle.net/11336/110101 |
| Rights: |
info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| رقم الانضمام: |
edsbas.4631FF84 |
| قاعدة البيانات: |
BASE |