Academic Journal
Serum remnant lipoprotein cholesterol/triglyceride ratio as an index for screening familial type III hyperlipidaemia
| العنوان: | Serum remnant lipoprotein cholesterol/triglyceride ratio as an index for screening familial type III hyperlipidaemia |
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| المؤلفون: | Nakajima, Katsuyuki, Daimon, Masahiro, Kamiyama, Kiyoshi, Takanashi, Kunihiko, Suzuki, Yukiko, Watanabe, Masakazu, Kubono, Katsuo, Saniabadi, Abby R, Takashima, Sei-Ichi, Sakurabayashi, Ikunosuke |
| المصدر: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine ; volume 44, issue 4, page 353-359 ; ISSN 0004-5632 1758-1001 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2007 |
| الوصف: | Background: An elevated serum remnant lipoprotein cholesterol (RLP-C)/triglyceride (TG) ratio has not been evaluated as an index of familial type III hyperlipidaemia defined by the presence of β-VLDL and apolipoprotein (Apo) E2/2 phenotype in the Japanese hyperlipidaemic population. Methods: Serum lipids and lipoproteins from 514 individuals (200 men and 314 women, mean age 58 years) with total cholesterol >6.22 mmol/L and TG between 2.26 mmol/L and 9.04 mmol/L, selected from 25,080 subjects visiting the clinics for health checkup were analysed for a possible relationship with familial type III hyperlipoproteinaemia. Results: Median RLP-C concentration and RLP-C/TG ratio were 0.30 and 0.11 mmol/L, respectively. When compared between subjects with (31 cases) and without (483 cases) a broad-beta band on electrophoresis, the RLP-C concentrations and RLP-C/TG ratio were 0.77±0.43 mmol/L versus 0.34±0.16 mmol/L ( P<0.0001) and 0.15±0.023 versus 0.11±0.027 ( P<0.0001), respectively. Three cases with broad-beta band positive (the presence of β-VLDL) showed RLP-C/TG ratio greater than 0.23 and RLP-C greater than 0.78 mmol/L, suggestive of type III hyperlipoproteinaemia, despite a lack of characteristic Apo E2/2 homozygosity. Cases with Apo E/Apo CIII ratio greater than 1.0 were not detected in this study group. Conclusion: Serum RLP-C concentration and RLP-C/TG ratio, together with Apo E/Apo CIII ratio appear to be useful for screening familial type III hyperlipidaemia in the Japanese hyperlipidaemic population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1258/000456307780945787 |
| الاتاحة: | https://doi.org/10.1258/000456307780945787 https://journals.sagepub.com/doi/pdf/10.1258/000456307780945787 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.460FDDE8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1258/000456307780945787 |
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