Academic Journal
Chain Length Effect of the Multidentate Block Copolymer Strategy to Stabilize Ultrasmall Fe 3 O 4 Nanoparticles
| العنوان: | Chain Length Effect of the Multidentate Block Copolymer Strategy to Stabilize Ultrasmall Fe 3 O 4 Nanoparticles |
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| المؤلفون: | Chan, Nicky, Li, Puzhen, Oh, Jung Kwon |
| المصدر: | ChemPlusChem ; volume 79, issue 9, page 1342-1351 ; ISSN 2192-6506 2192-6506 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2014 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | A multidentate block copolymer (MDBC) strategy to stabilize ultrasmall superparamagnetic iron oxide nanoparticles (USNPs) as biocompatible T 1 ‐positive contrast agents for magnetic resonance imaging (MRI) is explored. The MDBC is designed with a poly(methacrylic acid) (PMAA) block having pendant carboxylates as multidentate anchoring groups and a hydrophilic polymethacrylate block having pendant oligo(ethylene oxide) chains (POEOMA). A series of multifunctional MDBCs with different chain lengths of POEOMA and PMAA blocks were synthesized by atom transfer radical polymerization and subsequent hydrolytic cleavage. The resultant aqueous MDBC/USNP colloids fabricated through a ligand‐exchange process were characterized to investigate the effect of chain lengths of POEOMA‐ b ‐PMAA copolymers on size, morphology, and colloidal stability as well as relaxometric properties and in vitro MRI performance. The results suggest that the optimal design of chain lengths of both anchoring and hydrophilic blocks is required for enhanced colloidal stability under biologically relevant conditions as well as effective T 1 ‐weighted contrast enhancement. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/cplu.201402112 |
| DOI: | 10.1002/cplu.201402112/fullpdf |
| الاتاحة: | http://dx.doi.org/10.1002/cplu.201402112 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcplu.201402112 http://onlinelibrary.wiley.com/wol1/doi/10.1002/cplu.201402112/fullpdf |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.46049166 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cplu.201402112 |
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