Academic Journal
Association of MiR-146a and MiR196a2 Genotype with Susceptibility to Idiopathic Recurrent Pregnancy Loss in Iranian Women: A Case-control Study
| العنوان: | Association of MiR-146a and MiR196a2 Genotype with Susceptibility to Idiopathic Recurrent Pregnancy Loss in Iranian Women: A Case-control Study |
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| المؤلفون: | Babakhanzadeh, E. (Emad), Danaei, H. (Hamid), Abedinzadeh, M. (Mohammad), Ashrafzadeh, H. R. (Hamid), Ghasemi, N. (Nasrin) |
| المصدر: | International Journal of Reproductive BioMedicine |
| بيانات النشر: | Knowledge E Shahid Sadoughi University of Medical Sciences |
| سنة النشر: | 2021 |
| المجموعة: | neliti (Indonesia's Think Tank Database) |
| مصطلحات موضوعية: | Indonesia |
| الوصف: | Background: Recurrent pregnancy loss (RPL) is the most common complaint of pregnancy in females with a prevalence of 5%. Numerous documents have shown that single nucleotide polymorphisms are able to change miRNA transcription and/or maturation, which may alter the incidence of disorders such as RPL. Objective: To assess the relationship of miR-146aC > G (rs2910164) and miR-196a2T > C (rs11614913) with RPL susceptibility in Iranian women. Materials and Methods: Blood samples were collected from 214 women who had experienced at least two consecutive spontaneous miscarriages (case) and 147 normal individuals without a history of miscarriage (control). MiR-146aC > G and miR-196a2T > C genotypes were evaluated via the restriction fragment length polymorphism technique. Results: The genotypes incidence did not show a significant difference in pre-miR-146aC > G polymorphism CC vs CG + GG (p = 0.854; OR = 0.933; 95% CI) and CC + CG vs GG (p = 0.282; OR = 1.454; 95% CI). Also, no significant difference was observed between pre-miR-196a2T > C polymorphism TT vs TC + CC (p = 0.862; OR = 0.938; 95% CI) and TT + TC vs CC and (p = 0.291; OR = 1.462; 95% CI) in both the case and control groups. Conclusion: The results showed that although the distribution of miR-146aC > G and miR-196a2T > C was different between the unknown RPL and control groups, these variances were not statistically significant. Key words: RPL, miR-146a, miR196a2, Polymorphism, RFLP. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Indonesian |
| Relation: | https://www.neliti.com/publications/418833/association-of-mir-146a-and-mir196a2-genotype-with-susceptibility-to-idiopathic |
| الاتاحة: | https://www.neliti.com/publications/418833/association-of-mir-146a-and-mir196a2-genotype-with-susceptibility-to-idiopathic |
| Rights: | (c) International Journal of Reproductive BioMedicine, 2021 |
| رقم الانضمام: | edsbas.4600EB7E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |