Academic Journal
Novel function discovery with GeneMANIA: A new integrated resource for gene function prediction in Escherichia coli
| العنوان: | Novel function discovery with GeneMANIA: A new integrated resource for gene function prediction in Escherichia coli |
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| المؤلفون: | Vlasblom, J. (James), Zuberi, K. (Khalid), Rodriguez, H. (Harold), Arnold, R. (Roland), Gagarinova, A. (Alla), Deineko, V. (Viktor), Kumar, A. (Ashwani), Leung, E. (Elisa), Rizzolo, K. (Kamran), Samanfar, B. (Bahram), Chang, L. (Luke), Phanse, S. (Sadhna), Golshani, A. (Ashkan), Greenblatt, J.F. (Jack F.), Houry, W.A. (Walid A.), Emili, A. (Andrew), Morris, Q. (Quaid), Bader, G. (Gary), Babu, M. (Mohan) |
| المصدر: | Bioinformatics vol. 31 no. 3, pp. 306-310 |
| سنة النشر: | 2015 |
| المجموعة: | Carleton University's Institutional Repository |
| الوصف: | Motivation: The model bacterium Escherichia coli is among the best studied prokaryotes, yet nearly half of its proteins are still of unknown biological function. This is despite a wealth of available large-scale physical and genetic interaction data. To address this, we extended the GeneMANIA function prediction web application developed for model eukaryotes to support E.coli. Results: We integrated 48 distinct E.coli functional interaction datasets and used the GeneMANIA algorithm to produce thousands of novel functional predictions and prioritize genes for further functional assays. Our analysis achieved cross-validation performance comparable to that reported for eukaryotic model organisms, and revealed new functions for previously uncharacterized genes in specific bioprocesses, including components required for cell adhesion, iron-sulphur complex assembly and ribosome biogenesis. The GeneMANIA approach for network-based function prediction provides an innovative new tool for probing mechanisms underlying bacterial bioprocesses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://ir.library.carleton.ca/pub/8415 |
| DOI: | 10.1093/bioinformatics/btu671 |
| الاتاحة: | https://ir.library.carleton.ca/pub/8415 https://doi.org/10.1093/bioinformatics/btu671 |
| رقم الانضمام: | edsbas.45FE3908 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/bioinformatics/btu671 |
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