Academic Journal
Enhancement of Odorant-Induced Response in Olfactory Recptor Neurons by Zinc Nanoparticles
| العنوان: | Enhancement of Odorant-Induced Response in Olfactory Recptor Neurons by Zinc Nanoparticles |
|---|---|
| المؤلفون: | Nilmini Viswaprakash, John C. Dennis, Ludmila Globa, Oleg Pustovyy, Eleanor M. Josephson, Patrick Kanju, Edward E. Morrison, Vitaly J. Vodyanoy |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://chemse.oxfordjournals.org/content/34/7/547.full.pdf. |
| سنة النشر: | 2009 |
| المجموعة: | CiteSeerX |
| مصطلحات موضوعية: | Key words, cAMP, electroolfactogram, G-protein, metal nanoparticles, metals, whole-cell recording, zinc |
| الوصف: | Zinc metal nanoparticles in picomolar concentrations strongly enhance odorant responses of olfactory sensory neurons. One-to 2-nm metallic particles contain 40–300 zinc metal atoms, which are not in an ionic state. We exposed rat olfactory epithelium to metal nanoparticles and measured odorant responses by electroolfactogram and whole-cell patch clamp. A small amount of zinc nanoparticles added to an odorant or an extracellular/intracellular particle perfusion strongly increases the odorant response in a dose-dependent manner. Zinc nanoparticles alone produce no odor effects. Copper, gold, or silver nanoparticles do not produce effects similar to those of zinc. If zinc nanoparticles are replaced by Zn+2 ions in the same concentration range, we observed a reduction of the olfactory receptor neuron odorant response. Based on these observations, we hypothesize that zinc nanoparticles are closely located to the interface between the guanine nucleotide-binding protein and the receptor proteins and are involved in transferring signals in the initial events of olfaction. Our results suggest that zinc metal nanoparticles can be used to enhance and sustain the initial olfactory events. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1026.9420; http://chemse.oxfordjournals.org/content/34/7/547.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1026.9420 http://chemse.oxfordjournals.org/content/34/7/547.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.459BF52F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |