Academic Journal
Driving regeneration, instead of healing, in adult mammals ; Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis
| العنوان: | Driving regeneration, instead of healing, in adult mammals ; Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis |
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| المؤلفون: | Rabiller, Lise, Robert, Virginie, Arlat, Adèle, Labit, Elodie, Ousset, Marielle, Salon, Marie, Coste, Agnès, da Costa-Fernandes, Léa, Monsarrat, Paul, Ségui, Bruno, André, Mireille, Guissard, Christophe, Renoud, Marie-Laure, Silva, Marine, Mithieux, Gilles, Raymond-Letron, Isabelle, Pénicaud, Luc, Lorsignol, Anne, Casteilla, Louis, Dromard Berthézène, Cécile, Cousin, Béatrice |
| المساهمون: | Geroscience and rejuvenation research center (RESTORE), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Nutrition, diabète et cerveau (NUDICE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-16-CE14-0006,WAT-HEART,Pathologies ischémiques cardiaques et diabète : Rôle de l'hématopoïèse du tissu adipeux(2016) |
| المصدر: | ISSN: 2057-3995 ; NPJ Regenerative medicine ; https://hal.science/hal-03367206 ; NPJ Regenerative medicine, 2021, 6 (1), pp.41. ⟨10.1038/s41536-021-00151-1⟩. |
| بيانات النشر: | HAL CCSD Springer Nature |
| سنة النشر: | 2021 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | resident macrophages, efferocytosis, Cell biology, Immunology, Physiology, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Tissue repair after lesion usually leads to scar healing and thus loss of function in adult mammals. In contrast, other adult vertebrates such as amphibians have the ability to regenerate and restore tissue homeostasis after lesion. Understanding the control of the repair outcome is thus a concerning challenge for regenerative medicine. We recently developed a model of induced tissue regeneration in adult mice allowing the comparison of the early steps of regenerative and scar healing processes. By using studies of gain and loss of function, specific cell depletion approaches, and hematopoietic chimeras we demonstrate here that tissue regeneration in adult mammals depends on an early and transient peak of granulocyte producing reactive oxygen species and an efficient efferocytosis specifically by tissue-resident macrophages. These findings highlight key and early cellular pathways able to drive tissue repair towards regeneration in adult mammals. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-680901-2 0-00-680901-4 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34344890; hal-03367206; https://hal.science/hal-03367206; https://hal.science/hal-03367206/document; https://hal.science/hal-03367206/file/s41536-021-00151-1.pdf; PUBMED: 34344890; PUBMEDCENTRAL: PMC8333253; WOS: 000680901400001 |
| DOI: | 10.1038/s41536-021-00151-1 |
| الاتاحة: | https://hal.science/hal-03367206 https://hal.science/hal-03367206/document https://hal.science/hal-03367206/file/s41536-021-00151-1.pdf https://doi.org/10.1038/s41536-021-00151-1 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.459B5B63 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780006809012 0006809014 |
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| DOI: | 10.1038/s41536-021-00151-1 |