Academic Journal

Inhibition of the medial amygdala disrupts escalated aggression in lactating female mice after repeated exposure to male intruders

التفاصيل البيبلوغرافية
العنوان: Inhibition of the medial amygdala disrupts escalated aggression in lactating female mice after repeated exposure to male intruders
المؤلفون: Abellán-Álvaro, María, Martinez-Garcia, Fernando, Agustín-Pavón, Carmen
بيانات النشر: Nature Research
سنة النشر: 2022
المجموعة: Repositori Universitat Jaume I (Repositorio UJI)
مصطلحات موضوعية: lactating female, male intruders, mice, amygdala, social behaviour, olfactory system
الوصف: Virgin female laboratory mice readily express pup care when co-housed with dams and pups. However, pup-sensitized virgins fail to express intruder-directed aggression on a single session of testing. To study whether repeated testing would affect the onset and dynamics of maternal or intruder-directed aggression, we tested dams and their accompanying virgins from postpartum day 4 to 6. Repeated testing led to escalated aggression towards male intruders in dams, but virgins never developed aggression. In dams, inhibition of the medial amygdala using DREADD (designer receptors exclusively activated by designer drugs) vectors carrying the hM4Di receptor blocked the expected increase in maternal aggression on the second testing day. Our data support that the onset of maternal aggression is linked to physiological changes occurring during motherhood, and that medial amygdala, a key centre integrating vomeronasal, olfactory and hormonal information, enables the expression of escalated aggression induced by repeated testing. Future studies selectively targeting specific neuronal populations of the medial amygdala are needed to allow a deeper understanding of the control of experience-dependent aggression increase, a phenomenon leading to the high aggression levels found in violent behaviours.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
Relation: Commun Biol 5, 980 (2022); Abellán-Álvaro, M., Martínez-García, F., Lanuza, E. et al. Inhibition of the medial amygdala disrupts escalated aggression in lactating female mice after repeated exposure to male intruders. Commun Biol 5, 980 (2022). https://doi.org/10.1038/s42003-022-03928-2; http://hdl.handle.net/10234/200832; https://doi.org/10.1038/s42003-022-03928-2
DOI: 10.1038/s42003-022-03928-2
الاتاحة: http://hdl.handle.net/10234/200832
https://doi.org/10.1038/s42003-022-03928-2
Rights: © The Author(s) 2022 ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.45570356
قاعدة البيانات: BASE
الوصف
DOI:10.1038/s42003-022-03928-2