Academic Journal
Validation of the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake: an analysis of data from a prospective cohort study
| العنوان: | Validation of the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake: an analysis of data from a prospective cohort study |
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| المؤلفون: | Israelsen, Mads, Torp, Nikolaj, Johansen, Stine, Hansen, Camilla Dalby, Hansen, Emil Deleuran, Thorhauge, Katrine, Hansen, Johanne Kragh, Villesen, Ida, Bech, Katrine, Wernberg, Charlotte, Andersen, Peter, Lindvig, Katrine Prier, Tsochatzis, Emmanuel A, Thiele, Maja, Rinella, Mary E, Krag, Aleksander, GALAXY Consortium |
| المصدر: | The Lancet Gastroenterology & Hepatology , 9 (3) pp. 218-228. (2024) |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2024 |
| المجموعة: | University College London: UCL Discovery |
| الوصف: | Background: Steatotic liver disease is a new overarching term that includes metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-related steatotic liver disease (MetALD), and alcohol-related liver disease (ALD). We aimed to validate the prognostic importance of MASLD, MetALD, and ALD as steatotic liver disease subclasses. // Methods: Between April 18, 2013, and Sept 17, 2018, we prospectively recruited patients aged 18–75 years with current or previous excessive alcohol intake (>24 g/day for women and >36 g/day for men) for at least a year and no previous hepatic decompensation from the Department of Gastroenterology and Hepatology at Odense University Hospital (Odense, Denmark). Participants were followed up until Sept 15, 2022. Here, we characterise these patients according to steatotic liver disease subclasses. We classified patients as having MASLD, MetALD, or ALD in accordance with the nomenclature definitions, on the basis of metabolic comorbidity and self-reported average alcohol intake in the 3 months leading up to inclusion. Histological scoring was done by a pathologist who was masked to the clinical data. We compared prognoses between classes using Cox regression analyses on hepatic decompensation and overall mortality as the two outcome measures. Patients not meeting the criteria for steatotic liver disease were classified as no steatotic liver disease and served as a reference group. // Findings: We enrolled 446 patients with a history of excessive alcohol intake were included in this analysis (334 [75%] were male and 112 [25%] were female; median age 56 years [SD 10]). Cirrhosis was present in 58 (13%), and 435 (98%) had at least one cardiometabolic risk factor. 321 (72%) met steatotic liver disease criteria and 125 (28%) did not have steatotic liver disease, meaning no evident liver steatosis and no significant fibrosis (≥F2). Of the 321 patients with steatotic liver disease, six (2%) were identified as having ALD due to the absence of ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10187050/1/Tsochatzis_Validation%20of%20the%20new%20nomenclature%20of%20SLD_R1TC_V3MR%20%281%29_MI.pdf; https://discovery.ucl.ac.uk/id/eprint/10187050/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10187050/1/Tsochatzis_Validation%20of%20the%20new%20nomenclature%20of%20SLD_R1TC_V3MR%20%281%29_MI.pdf https://discovery.ucl.ac.uk/id/eprint/10187050/ |
| Rights: | open |
| رقم الانضمام: | edsbas.4551E333 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |