Academic Journal
Behavior Genetics (Ó 2006) DOI:10.1007/s10519-006-9058-7 Selective Breeding for Divergence in Novelty-seeking Traits: Heritability and Enrichment in Spontaneous Anxiety-related Behaviors
| العنوان: | Behavior Genetics (Ó 2006) DOI:10.1007/s10519-006-9058-7 Selective Breeding for Divergence in Novelty-seeking Traits: Heritability and Enrichment in Spontaneous Anxiety-related Behaviors |
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| المؤلفون: | John D. H. Stead, Sarah Clinton, Charles Neal, Johanna Schneider, Abas Jama, Sue Miller, Delia M. Vazquez, Stanley J. Watson, Huda Akil |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://deepblue.lib.umich.edu/bitstream/handle/2027.42/42783/10519_2006_Article_9058.pdf;jsessionid=5DE77DFDE377DB1DA0EF2374B461BEEA?sequence=1. |
| سنة النشر: | 2005 |
| المجموعة: | CiteSeerX |
| الوصف: | Outbred Sprague Dawley rats can be classified as high responders (HR) or low responders (LR) based on their levels of exploratory locomotion in a novel environment. While this novelty-seeking dimension was originally related to differential vulnerability to substance abuse, behavioral, neuroendocrine and gene expression studies suggest a fundamental difference in emotional reactivity between these animals. Here, we report the first study to selectively breed rats based on this novelty-seeking dimension. Response to novelty was clearly heritable, with a>2-fold difference in behavior seen after eight generations of selection. Three tests of anxiety-like behavior consistently showed significantly greater anxiety in LR-bred rats compared to HR-bred animals, and this difference was diminished in the open field test by administration of the anxiolytic benzodiazepine drug, chlordiazepoxide. Cross-fostering revealed that responses to novelty were largely unaffected by maternal interactions, though there was an effect on anxiety-like behavior. These selected lines will enable future research on the interplay of genetic, environmental and developmental variables in controlling drug seeking behavior, stress and emotional reactivity. KEY WORDS: High responder; individual differences; low responder; reactivity to novelty; selective breeding; stress. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.2083; http://deepblue.lib.umich.edu/bitstream/handle/2027.42/42783/10519_2006_Article_9058.pdf;jsessionid=5DE77DFDE377DB1DA0EF2374B461BEEA?sequence=1 |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.2083 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/42783/10519_2006_Article_9058.pdf;jsessionid=5DE77DFDE377DB1DA0EF2374B461BEEA?sequence=1 |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.454C1E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |