Academic Journal
Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia
| العنوان: | Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia |
|---|---|
| المؤلفون: | Martínez Boubeta, Carlos, Balcells, Lluis, Cristòfol, Rosa, Sanfeliu, Coral, Sandiumenge, Felip, Calleja Lázaro, Alberto, Martínez Perea, Benjamín |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2010 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| الوصف: | El pdf del artículo es el manuscrito de autor.-- et al. ; A one-step process for the production of nanoparticles presenting advanced magnetic properties can be achieved using vapor condensation. In this article, we report on the fabrication of Fe particles covered by a uniform MgO epitaxial shell. MgO has a lower surface energy than Fe, which results in a core-shell crystal formation. The particles satisfy a few of technical requirements for the practical use in real clinics, such as a high biocompatibility in living cells in-vitro, an injection through blood vessels without any clothing problems in murine model, a high absorption rate for magnetic hyperthermia at small particle concentration, and the potential to be used as contrast agent in the field of diagnostic magnetic imaging. They are also able to be used in drug delivery and magnetic-activated cell sorting. From the Clinical Editor: In this paper, the authors report on the synthesis of Fe particles covered by a uniform MgO epitaxial shell resulting in a core-shell crystal formation. The particles are proven to be useful as contrast agents for magnetic resonance imaging and have the potential to be useful as heating mediators for cancer therapy through hyperthermia. They also might be used in drug delivery and magnetic-activated cell sorting. © 2010 Elsevier Inc. All rights reserved. ; This work was supported by the Spanish MEC (MAT2006-13572-C02-01 and SAF2006-13092-C02-02), CONSOLIDER (CSD2007-00041), ISCIII (RD06/0013/1004), FEDER program and Generalitat de Catalunya (2005SGR-00509). This work was partially funded by EC project SOLFACE in the frame of the 6ePCRDT program. C. M-B. thanks the Spanish MEC for financial support through the Juan de la Cierva & Ramon y Cajal programs. E. R. kindly acknowledges the EC-Marie Curie grant OIF (Molecular Imaging 39693). ; Peer Reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | http://dx.doi.org/10.1016/j.nano.2009.09.003; http://hdl.handle.net/10261/77663 |
| DOI: | 10.1016/j.nano.2009.09.003 |
| الاتاحة: | http://hdl.handle.net/10261/77663 https://doi.org/10.1016/j.nano.2009.09.003 |
| Rights: | open |
| رقم الانضمام: | edsbas.450B3B56 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.nano.2009.09.003 |
|---|