التفاصيل البيبلوغرافية
| العنوان: |
Association of Fibrinolytic Potential and Risk of Mortality in Cancer Patients |
| المؤلفون: |
Gabriele Silva Souza Gois, Silmara Aparecida Lima Montalvão, Thaizy Ramires Alencar Anhaia, Millene Evelyn Alves Almeida, Beatriz Moraes Martinelli, Maria Carmen Gonçalves Lopes Fernandes, Stephany Cares Hubers, Monique R. M. Ferreira, Daniel Dias Ribeiro, Júlio César Teixeira, José Barreto Campello Carvalheira, Carmen Silvia Passos Lima, Nelson Adami Andreollo, Maurício Etchebehere, Lair Zambon, Ubirajara Ferreira, Alfio José Tincani, Antônio Santos Martins, Cláudio Saddy Rodrigues Coy, José Cláudio Teixeira Seabra, Ricardo Kalaf Mussi, Helder Tedeschi, Joyce Maria Anninchino-Bizzacchi, ADVENTH Cancer Group ADVENTH Cancer Group |
| المصدر: |
Cancers ; Volume 15 ; Issue 17 ; Pages: 4408 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
fibrinolysis, plasmin, thrombin, cancer, mortality, STP |
| الوصف: |
Cancer is a leading cause of death, and the fibrinolytic system shows cooperative effects that facilitate the growth of tumors and the appearance of metastases. This prospective study aimed to evaluate the fibrinolytic potential in cancer patients and its association with mortality outcomes using the fluorometric method of simultaneous thrombin and plasmin generation. The study included 323 cancer patients and 148 healthy individuals. During the 12-month follow-up, 68 patients died. Compared to the control group, cancer patients showed alterations in thrombin production consistent with a hypercoagulability profile, and an increase in plasmin generation. Mortality risk was associated with two parameters of thrombin in both univariate and multivariable analysis: maximum amplitude (Wald 11.78, p < 0.001) and area under the curve (Wald 8.0, p < 0.005), while such associations were not observed for plasmin. In conclusion, this was the first study able to demonstrate the simultaneous evaluation of thrombin and plasmin generation in newly diagnosed untreated cancer patients. Patients with cancer have been observed to exhibit a hypercoagulable profile. During the study, two parameters linked to thrombin generation, MA and AUC, were identified and found to have a potential association with mortality risk. However, no associations were found with parameters related to plasmin generation. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Cancer Epidemiology and Prevention; https://dx.doi.org/10.3390/cancers15174408 |
| DOI: |
10.3390/cancers15174408 |
| الاتاحة: |
https://doi.org/10.3390/cancers15174408 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.44D6566A |
| قاعدة البيانات: |
BASE |