Book
Direct Nucleophilic Substitution of Alcohols by Brønsted or Lewis Acids Activation: An Update
| العنوان: | Direct Nucleophilic Substitution of Alcohols by Brønsted or Lewis Acids Activation: An Update |
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| المؤلفون: | Cozzi P. G., Gualandi A., Mengozzi L., Manoni E., Wilson C. M. |
| المساهمون: | Paul F. Richardson, Cozzi P.G., Gualandi A., Mengozzi L., Manoni E., Wilson C.M. |
| بيانات النشر: | Springer Nature Switzerland AG CHE Svizzera |
| سنة النشر: | 2022 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Alcohol, Brønsted acid, Carbenium ion, Cascade reaction, Diastereoselectivity, Direct nucleophilic substitution, Enantioselectivity, Lewis acid, Mayr scale, Meyer–Schuster rearrangement, Piancatelli rearrangement |
| الوصف: | Typically substitution of alcohols involves a two-step activation/displacement pathway thus leading to the generation of additional waste. The current chapter considers an alternative reaction manifold with the displacement taking place directly through activation of the alcohol by either a Lewis or Brønsted acid. With particular focus on the literature since 2011, an initial overview of carbenium ion reactivity is provided followed by a survey of displacement reactions grouped by the nature of the nucleophile. Finally, advances in both diastereoselective and enantioselective variants of the reaction are discussed. |
| نوع الوثيقة: | book part |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/isbn/978-1-0716-1577-5; info:eu-repo/semantics/altIdentifier/isbn/978-1-0716-1579-9; ispartofbook:Green Chemistry in Drug Discovery; firstpage:123; lastpage:154; numberofpages:32; serie:METHODS IN PHARMACOLOGY AND TOXICOLOGY; alleditors:Paul F. Richardson; http://hdl.handle.net/11585/849852; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85121488285; https://link.springer.com/protocol/10.1007/978-1-0716-1579-9_4 |
| DOI: | 10.1007/978-1-0716-1579-9_4 |
| الاتاحة: | http://hdl.handle.net/11585/849852 https://doi.org/10.1007/978-1-0716-1579-9_4 https://link.springer.com/protocol/10.1007/978-1-0716-1579-9_4 |
| رقم الانضمام: | edsbas.44B6035A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/978-1-0716-1579-9_4 |
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