Academic Journal
The utilization of physiologically active molecular components of grape seeds and grape marc
| العنوان: | The utilization of physiologically active molecular components of grape seeds and grape marc |
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| المؤلفون: | Hegedüs, Imre, Andreidesz, Kitti, Szentpéteri, József L., Kaleta, Zoltán, Szabó, László, Szigeti, Krisztián, Gulyás, Balázs, Padmanabhan, Parasuraman, Budan, Ferenc, Máthé, Domokos |
| المساهمون: | Lee Kong Chian School of Medicine (LKCMedicine) |
| سنة النشر: | 2022 |
| المجموعة: | DR-NTU (Digital Repository at Nanyang Technological University, Singapore) |
| مصطلحات موضوعية: | Science::Chemistry, Grape, Polyphenols |
| الوصف: | Nutritional interventions may highly contribute to the maintenance or restoration of human health. Grapes (Vitis vinifera) are one of the oldest known beneficial nutritional components of the human diet. Their high polyphenol content has been proven to enhance human health beyond doubt in statistics-based public health studies, especially in the prevention of cardiovascular disease and cancer. The current review concentrates on presenting and classifying polyphenol bioactive molecules (resveratrol, quercetin, catechin/epicatechin, etc.) available in high quantities in Vitis vinifera grapes or their byproducts. The molecular pathways and cellular signaling cascades involved in the effects of these polyphenol molecules are also presented in this review, which summarizes currently available in vitro and in vivo experimental literature data on their biological activities mostly in easily accessible tabular form. New molecules for different therapeutic purposes can also be synthesized based on existing polyphenol compound classes available in high quantities in grape, wine, and grape marc. Therefore an overview of these molecular structures is provided. Novel possibilities as dendrimer nanobioconjugates are reviewed, too. Currently available in vitro and in vivo experimental literature data on polyphenol biological activities are presented in easily accessible tabular form. The scope of the review details the antidiabetic, anticarcinogenic, antiviral, vasoprotective, and neuroprotective roles of grape-origin flavonoids. The novelty of the study lies in the description of the processing of agricultural by-products (grape seeds and skins) of industrial relevance, and the detailed description of the molecular mechanisms of action. In addition, the review of the clinical therapeutic applications of polyphenols is unique as no summary study has yet been done. ; Published version ; This research was supported by the Higher Education Institutional Excellence Program of the Ministry of Innovation and Technology, ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1661-6596 36232467 |
| Relation: | International Journal of Molecular Sciences; Hegedüs, I., Andreidesz, K., Szentpéteri, J. L., Kaleta, Z., Szabó, L., Szigeti, K., Gulyás, B., Padmanabhan, P., Budan, F. & Máthé, D. (2022). The utilization of physiologically active molecular components of grape seeds and grape marc. International Journal of Molecular Sciences, 23(19), 11165-. https://dx.doi.org/10.3390/ijms231911165; https://hdl.handle.net/10356/171007; 2-s2.0-85139979135; 19; 23; 11165 |
| DOI: | 10.3390/ijms231911165 |
| الاتاحة: | https://hdl.handle.net/10356/171007 https://doi.org/10.3390/ijms231911165 |
| Rights: | © 2022 The authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
| رقم الانضمام: | edsbas.44A6CC53 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16616596 36232467 |
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| DOI: | 10.3390/ijms231911165 |